Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends
Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends
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DOI：
10.1136/jnnp.2007.117655
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发表时间：
2007-12-01
影响因子：
11
通讯作者：
Rinkel, G. J. E.
中科院分区：
文献类型：
--
作者：
de Rooij, N. K.;Linn, F. H. H.;Rinkel, G. J. E.
背景和目标：更新我们的1996年审查蛛网膜下腔出血（SAH）的发病率，并评估发病率与地区，年龄，性别和timeperiod.Methods的关系：我们搜索的研究，直到2005年10月发表的SAH的发病率。计算总发生率及相应的95%置信区间。我们确定了SAH的发病率和决定因素之间的关系，通过单变量Poisson regression.Results：我们纳入了51项研究（33个新的），描述了21个国家的58个研究人群，观察45 821 896人年。日本每10万人年的发病率为22.7（95% CI 21.9 - 23.5），芬兰为19.7（18.1 - 21.3），南美洲和中美洲为4.2（3.1 - 5.7），其他地区为9.1（8.8 - 9.5）。以45-55岁年龄组为参考，发病率从25岁以下年龄组的0.10（0.08 - 0.14）增加到85岁以上年龄组的1.61（1.24 - 2.07）。女性的发病率是男性的1.24倍（1.09至1.42）;这种性别差异始于55岁，此后有所增加。1950年至2005年，发病率下降了0.6%（1.3%下降到0.1%增加）每年。结论：SAH的总发病率约为每10万人年9。日本和芬兰的发病率更高，而且随着年龄的增长而增加。妇女的优势只是在第六个十年才开始。在过去的45年中，SAH的发病率下降与一般卒中相比相对温和。
Background and aim: To update our 1996 review on the incidence of subarachnoid haemorrhage (SAH) and assess the relation of incidence with region, age, gender and time period.Methods: We searched for studies on the incidence of SAH published until October 2005. The overall incidences with corresponding 95% confidence intervals were calculated. We determined the relationship between the incidence of SAH and determinants by means of univariate Poisson regression.Results: We included 51 studies (33 new), describing 58 study populations in 21 countries, observing 45 821 896 person-years. Incidences per 100 000 person-years were 22.7 (95% CI 21.9 to 23.5) in Japan, 19.7 (18.1 to 21.3) in Finland, 4.2 (3.1 to 5.7) in South and Central America, and 9.1 (8.8 to 9.5) in the other regions. With age category 45-55 years as the reference, incidence ratios increased from 0.10 (0.08 to 0.14) for age groups younger than 25 years to 1.61 (1.24 to 2.07) for age groups older than 85 years. The incidence in women was 1.24 (1.09 to 1.42) times higher than in men; this gender difference started at age 55 years and increased thereafter. Between 1950 and 2005, the incidence decreased by 0.6% (1.3% decrease to 0.1% increase) per year.Conclusions: The overall incidence of SAH is approximately 9 per 100 000 person-years. Rates are higher in Japan and Finland and increase with age. The preponderance of women starts only in the sixth decade. The decline in incidence of SAH over the past 45 years is relatively moderate compared with that for stroke in general.