Naked-Eye Visible Solid Illicit Drug Detection at Picogram Level via a Multiple-Anchored Fluorescent Probe
Naked-Eye Visible Solid Illicit Drug Detection at Picogram Level via a Multiple-Anchored Fluorescent Probe
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通过多锚定荧光探针在皮克级进行肉眼可见固体非法药物检测
DOI：
10.1021/acssensors.5b00293
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发表时间：
2016-03-01
期刊：
影响因子：
8.9
通讯作者：
Cheng, Jiangong
中科院分区：
文献类型：
--
作者：
Fan, Tianchi;Xu, Wei;Cheng, Jiangong
固态荧光探针具有溶液荧光探针的缺点，也不需要对分析物进行任何预处理，因此在滥用药物的检测中具有很大的需求。滥用药物以盐的形式存在，反应性和挥发性较低，固体荧光传感检测面临很大挑战。在这项工作中，第一次，一个简单的，快速的，灵敏的，和选择性的固态荧光探针-分子内二聚体的8个苯甲醇取代的芴桥接的1，6-己基单元（8BA-2F）-已被设计，合成，并用于在接触模式下检测氯胺酮和甲基苯丙胺的药物的预处理。当与不同浓度的药物接触时，发射将显示不同的发射颜色，这可以用肉眼看到。即使是50 pg/cm 2的氯胺酮也可以通过肉眼检测到。理论计算表明，两种分子间存在较强的氢键相互作用。
Solid-state fluorescence probes, without the disadvantages of the existing probe in solution or any pretreatment needed for the analytes, are in great need for the detection of abused drugs. The abused drugs exist as salts, which have low reactivity and volatility, so there is a big challenge for the detection using the solid fluorescence sensing method. In this work, for the first time, a simple, rapid, sensitive, and selective solid-state fluorescence probe—an intramolecular dimer of eight benzyl alcohol-substituted fluorenes bridged by a 1,6-hexanyl unit (8BA-2F)—has been designed, synthesized, and used in a contact mode for ketamine and methylamphetamine detection without the pretreatment of the drugs. Upon contact with the drugs in different concentrations, the emission will show a different emission color, which could be visible with the naked eye. Even 50 pg/cm2 ketamine could be detected by the naked eye. Theoretical calculation indicates that there is strong hydrogen bonding interaction between t...