Celastrol: The new dawn in the treatment of vascular remodeling diseases.
Celastrol: The new dawn in the treatment of vascular remodeling diseases.
复制标题
DOI：
10.1016/j.biopha.2022.114177
复制
发表时间：
2023-02
期刊：
影响因子：
--
通讯作者：
Junlan Tan;Jian Yi;Xian Cao;Fei-Ying Wang;Silin Xie;Ling-Ling Zhou-Ling;Li Qin;A. Dai
中科院分区：
文献类型：
--
作者：
Junlan Tan;Jian Yi;Xian Cao;Fei-Ying Wang;Silin Xie;Ling-Ling Zhou-Ling;Li Qin;A. Dai
越来越多的证据表明，异常的血管重塑导致许多心血管疾病（CVD）。这表明血管重塑可能是预防和治疗CVD的关键目标。雷公藤红素是雷公藤中的一种有效成分，近年来因其改善血管重塑的作用而引起广泛关注。大量证据表明雷公藤红素通过改善炎症、过度增殖和血管平滑肌细胞的迁移、血管钙化、内皮功能障碍、细胞外基质重塑和血管生成来改善血管重塑。此外，许多报道已经证明雷公藤红素的积极作用及其在治疗血管重塑疾病如高血压、动脉粥样硬化和肺动脉高压中的治疗前景。本文就雷公藤红素调节血管重构的分子机制进行综述和探讨，为雷公藤红素的临床应用提供基础研究依据。
Evidence is mounting that abnormal vascular remodeling leads to many cardiovascular diseases (CVDs). This suggests that vascular remodeling can be a crucial target for the prevention and treatment of CVDs. Recently, celastrol, an active ingredient of the broadly used Chinese herbTripterygium wilfordii Hook F, has attracted extensive interest for its proven potential to improve vascular remodeling. Substantial evidence has shown that celastrol improves vascular remodeling by ameliorating inflammation, hyperproliferation, and migration of vascular smooth muscle cells, vascular calcification, endothelial dysfunction, extracellular matrix remodeling, and angiogenesis. Moreover, numerous reports have proven the positive effects of celastrol and its therapeutic promise in treating vascular remodeling diseases such as hypertension, atherosclerosis, and pulmonary artery hypertension. The present review summarizes and discusses the molecular mechanism of celastrol regulating vascular remodeling and provides preclinical proof for future clinical applications of celastrol.