GATA transcription factors as tissue-specific master regulators for induced responses.
GATA transcription factors as tissue-specific master regulators for induced responses.
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DOI：
10.1080/21624054.2015.1118607
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Shapira M
中科院分区：
文献类型：
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作者：
Block DH;Shapira M
加塔转录因子在指导发育遗传程序和细胞分化中起重要作用，并且在动物、植物和真菌中是保守的。C.线虫有11个GATA型转录因子，协调肠道、表皮和外阴的发育。然而，某些加塔蛋白的表达持续到成年期，在成年期，它们的功能还不太清楚。越来越多的证据表明，2个终末分化加塔转录因子ELT-2和ELT-3分别对成人肠和表皮（皮下组织）中的上皮免疫应答有贡献。参与其他压力反应也有记录。我们最近发现，ELT-2作为一个组织特异性的主调节因子，与p38通路激活的两个转录因子ATF-7和SKN-1合作，控制成年C.线虫肠在这里，我们讨论了更广泛的影响，这些研究结果的理解参与加塔转录因子在成人的压力反应，并绘制ELT-2和ELT-3之间的相似之处，推测后者可能履行类似的组织特异性功能的表皮。
GATA transcription factors play important roles in directing developmental genetic programs and cell differentiation, and are conserved in animals, plants and fungi. C. elegans has 11 GATA-type transcription factors that orchestrate development of the gut, epidermis and vulva. However, the expression of certain GATA proteins persists into adulthood, where their function is less understood. Accumulating evidence demonstrates contributions of 2 terminal differentiation GATA transcription factors, ELT-2 and ELT-3, to epithelial immune responses in the adult intestine and epidermis (hypodermis), respectively. Involvement in other stress responses has also been documented. We recently showed that ELT-2 acted as a tissue-specific master regulator, cooperating with 2 transcription factors activated by the p38 pathway, ATF-7 and SKN-1, to control immune responses in the adult C. elegans intestine. Here, we discuss the broader implications of these findings for understanding the involvement of GATA transcription factors in adult stress responses, and draw parallels between ELT-2 and ELT-3 to speculate that the latter may fulfill similar tissue-specific functions in the epidermis.