Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit.
Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit.
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作者：
Ding J;Chen A;Chung J;Acaron Ledesma H;Wu M;Berson DM;Palmer SE;Wei W
空间分布的兴奋和抑制共同塑造了视觉神经元的感受野（RF）特性。在哺乳动物视网膜的定向选择回路中，对开-关定向选择神经节细胞（on- off DSGCs）的强零方向抑制对其定向选择性的作用进行了深入的研究。然而，兴奋性输入如何影响开关DSGC的视觉反应尚不清楚。在这里，我们报道了开关DSGCs沿其水平优先空运动轴具有空间移位的谷氨酸能接受野。这种移位的感受野有助于DSGC在中断运动轨迹期间的零方向尖峰。理论分析表明，在复杂、自然的视觉环境中，群体在运动中断时的反应可能有助于群体的开关DSGCs发出运动物体的空间位置信号。我们的研究强调，方向选择电路在不同的刺激条件下利用不同的机制，这些机制可能有助于编码多种视觉特征。
Spatially distributed excitation and inhibition collectively shape a visual neuron’s receptive field (RF) properties. In the direction-selective circuit of the mammalian retina, the role of strong null-direction inhibition of On-Off direction-selective ganglion cells (On-Off DSGCs) on their direction selectivity is well-studied. However, how excitatory inputs influence the On-Off DSGC’s visual response is underexplored. Here, we report that On-Off DSGCs have a spatially displaced glutamatergic receptive field along their horizontal preferred-null motion axes. This displaced receptive field contributes to DSGC null-direction spiking during interrupted motion trajectories. Theoretical analyses indicate that population responses during interrupted motion may help populations of On-Off DSGCs signal the spatial location of moving objects in complex, naturalistic visual environments. Our study highlights that the direction-selective circuit exploits separate sets of mechanisms under different stimulus conditions, and these mechanisms may help encode multiple visual features.