Magnetization transfer MRI in pancreatic cancer xenograft models
Magnetization transfer MRI in pancreatic cancer xenograft models
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DOI：
10.1002/mrm.24127
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发表时间：
2012-10-01
影响因子：
3.3
通讯作者：
Larson, Andrew C.
中科院分区：
文献类型：
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作者：
Li, Weiguo;Zhang, Zhuoli;Larson, Andrew C.
在三种胰腺导管腺癌小鼠异种移植模型中进行磁化转移磁共振成像测量。对于 28 个胰腺导管腺癌异种移植物中的每一个，计算 MT 比率 (MTR)，并与参考标准三色染色的组织学纤维化水平进行比较。与 Panc-1 (32.4 +/- 2.8) 和 Capan-1 (27.3 +/- 2.9) 细胞系生长的肿瘤的 MTR 相比，使用 BxPC-3 细胞系生长的肿瘤的 MTR 显着更高（39.4 +/- 5.1，平均值 +/- SD）（每次比较 P < 0.05）。组织学测量结果显示，与 Panc-1 (3.54 +/- 2.18) 和 Capan-1 (2.07 +/- 1.60) 肿瘤相比，BxPC-3 肿瘤具有显着更高的纤维化水平（纤维化组织面积百分比，6.48 +/- 2.59）。 MTR 测量值与定量纤维化水平密切相关（r = 0.69，P = 0.01）。结果表明，MTR 测量有可能作为胰腺导管腺癌结缔组织形成的有价值的体内生物标志物。 Magn Reson Med，2012。(c) 2011 Wiley periodicals, Inc.
Magnetization transfer magnetic resonance imaging measurements were performed in three pancreatic ductal adenocarcinoma mouse xenograft models. For each of 28 pancreatic ductal adenocarcinoma xenografts, MT ratios (MTRs) were calculated and compared to histologic fibrosis levels from reference standard trichrome staining. MTR was found to be significantly higher in tumors grown using BxPC-3 cell line (39.4 +/- 5.1, mean +/- SD) compared to the MTR for the tumors grown from Panc-1 (32.4 +/- 2.8) and Capan-1 (27.3 +/- 2.9) cell lines (P < 0.05 for each comparison). Histologic measurements showed a similar trend with BxPC-3 tumors demonstrating significantly higher fibrosis levels (percentage of fibrotic tissue area, 6.48 +/- 2.59) when compared to Panc-1 (3.54 +/- 2.18) and Capan-1 (2.07 +/- 1.60) tumors. MTR measurements were well correlated to quantitative fibrosis levels (r = 0.69, P = 0.01). Results indicated that MTR measurements offer the potential to serve as a valuable in vivo biomarker of desmoplasia in pancreatic ductal adenocarcinoma. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.