Increased replication of HTLV‐I in HTLV‐I–associated myelopathy
Increased replication of HTLV‐I in HTLV‐I–associated myelopathy
复制标题
HTLV-I 相关脊髓病中 HTLV-I 复制增加
DOI：
10.1002/ana.410260304
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发表时间：
1989
影响因子：
11.2
通讯作者：
K. Usuku
中科院分区：
文献类型：
--
作者：
Mitsuaki Yoshida;M. Osame;H. Kawai;M. Toita;N. Kuwasaki;Y. Nishida;Y. Hiraki;Kouichi Takahashi;K. Nomura;S. Sonoda;N. Eiraku;S. Ijichi;K. Usuku
为了估计人T细胞白血病病毒I型（HTLV-I）在HTLV-I相关脊髓病（HAM）或热带痉挛性轻瘫（TSP）患者中的复制，通过Southern印迹杂交分析了整合到淋巴细胞基因组中的HTLV-I DNA。153例患者中有125例（82%）检测到HTLV‐I DNA，大多数显示随机整合。这一发生率远高于无症状携带者的29%。因此，HAM/TSP的发展与高水平的HTLV-I复制相关。此外，3名HAM/TSP患者的淋巴细胞显示HTLV-I DNA的单克隆整合，表明患有成人T细胞白血病。
To estimate the replication of the human T‐cell leukemia virus type I (HTLV‐I) in patients with HTLV‐I‐associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV‐I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV‐I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymtopmatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV‐I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV‐I DNA, indicating adult T‐cell leukemia.