Salivary cortisol is related to atherosclerosis of carotid arteries
Salivary cortisol is related to atherosclerosis of carotid arteries
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DOI：
10.1210/jc.2008-0496
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发表时间：
2008-10-01
影响因子：
5.8
通讯作者：
Tiemeier, H.
中科院分区：
文献类型：
--
作者：
Dekker, M. J. H. J.;Koper, J. W.;Tiemeier, H.
背景：下丘脑-垂体-肾上腺轴的失调被认为是缺血性心脏病的独立危险因素。本研究的目的是评估下丘脑-垂体-肾上腺轴活动的两个标志物，唾液皮质醇水平和昼夜唾液皮质醇模式，是否与老年人颈动脉粥样硬化相关。方法和结果：鹿特丹研究是一项老年人群队列研究，共有1866名参与者，在1天内提供4份唾液皮质醇样本，并进行超声检查以检查两个颈动脉的共同、内部和分叉部位中斑块的存在。计算两个单独的皮质醇值的汇总测量值：曲线下面积（AUC），这是清醒时皮质醇总暴露量的测量值;和斜率，这是昼夜皮质醇下降的测量值。（β = 0.08/AUC SD，95%置信区间0.00-0.16; P = 0.04）。AUC在最高三分位数的人与最低三分位数的人相比，颈动脉斑块数量更高（3.08 vs. 2.80，95%置信区间差异0.09-0.48; P = 0.005）。昼夜皮质醇下降和斑块scores.Conclusion：我们的研究结果支持这一假设，即增加总皮质醇暴露是独立相关的颈动脉粥样硬化。
Background: Dysregulation of the hypothalamic-pituitary-adrenal axis has been suggested as an independent risk factor for ischemic heart disease. The aim of our study was to evaluate whether two markers of the hypothalamic-pituitary-adrenal axis activity, the level of salivary cortisol and the diurnal salivary cortisol pattern, are associated with atherosclerosis of the carotid arteries in an elderly population.Methods and Results: A total of 1866 participants of the Rotterdam Study, a population-based cohort study in the elderly, provided four salivary cortisol samples throughout 1 d, and underwent ultrasonography to examine the presence of plaques in the common, internal, and bifurcation sites of both carotid arteries. Two summary measures of the separate cortisol values were computed: area under the curve (AUC), which is a measure of total cortisol exposure while awake; and the slope, which is a measure of diurnal cortisol decline.Results: Total cortisol exposure while awake (AUC) was associated with higher plaque scores (beta = 0.08 per SD of AUC, 95% confidence interval 0.00-0.16; P = 0.04) in a fully adjusted linear regression model. Persons with an AUC in the highest tertile had a higher number of plaques of carotid arteries compared with those in the lowest tertile (3.08 vs. 2.80, 95% confidence interval of difference 0.09-0.48; P = 0.005). There was no relation between diurnal cortisol decline and plaque score.Conclusion: Our results support the hypothesis that increased total cortisol exposure is independently associated with atherosclerosis of the carotid arteries.