Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus
Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus
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DOI：
10.1097/coh.0b013e3282faa461
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发表时间：
2008-05-01
影响因子：
4.1
通讯作者：
Watkins, David I.
中科院分区：
文献类型：
--
作者：
Friedrich, Thomas C.;Watkins, David I.
回顾的目的我们将强调最近的进展，在定义的属性控制艾滋病病毒复制的免疫反应，使用动物模型，并指出我们的理解，应在未来的研究中解决的关键差距。几乎所有这些都能引起猕猴强烈的细胞或体液免疫反应。常用的初免-加强策略在减少接种动物的慢性期病毒载量方面取得了不同程度的成功，但很少有人表现出与HIV田间分离株最相似的CCR 5嗜性猴免疫缺陷病毒（SIV）复制的持久减少。因此，研究人员正在转向其他系统，包括减毒活疫苗和自发SIV控制者队列，以帮助确定宿主对致病性SIV成功应答的特性。这些反应可能包括多个协调效应mechanism.SummaryThere是没有有效的艾滋病疫苗的地平线上。CD 4（+）和CD 8（+）T细胞反应和抗体都与在各种实验系统中观察到的SIV复制的控制有关，但是对抗AIDS病毒复制的保护的相关性还没有被确定。动物模型仍将是这项研究的必要组成部分。
Purpose of reviewWe will highlight recent advances in defining the attributes of immune responses that control AIDS virus replication using animal models, and also point out key gaps in our understanding that should be addressed in future research.Recent findingsMany different vaccine approaches are currently being evaluated in animal models. Almost all of them elicit strong cellular or humoral immune responses in macaques. Commonly used prime-and-boost strategies have had varying degrees of success in diminishing chronic phase virus loads in vaccinated animals, but few have shown durable reduction in replication of the CCR5-tropic simian immunodeficiency viruses (SIVs) that most closely resemble field isolates of HIV. Investigators are therefore turning to other systems, including live attenuated vaccines and cohorts of spontaneous SIV controllers, to help identify the properties of successful host responses to pathogenic SIV. These responses likely incorporate multiple coordinated effector mechanisms.SummaryThere is no effective AIDS vaccine on the horizon. CD4(+) and CD8(+) T cell responses and antibodies have all been implicated in control of SIV replication seen in various experimental systems, but the correlates of protection against AIDS virus replication have not yet been definitively identified. Animal models will remain a necessary component of this research.