Solid/liquid palladium-catalyzed coupling of haloaryls using alcohols as reducing agents: Kinetics and process optimization
Solid/liquid palladium-catalyzed coupling of haloaryls using alcohols as reducing agents: Kinetics and process optimization
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DOI：
10.1021/op015519
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发表时间：
2003-01-01
影响因子：
3.4
通讯作者：
Sasson, Y
中科院分区：
文献类型：
--
作者：
Gitis, D;Mukhopadhyay, S;Sasson, Y
在碱和催化量的相转移（PT）剂存在下，使用醇作为还原剂，在不同的有机溶剂中有效地进行多相Pd催化的取代卤代苯与联苯的偶联反应。醇被氧化成相应的醛或酮。动力学研究表明，卤代苯的反应速率方程符合二阶。研究并讨论了反应温度、催化剂负载量、碱浓度、PTC浓度、醇浓度和结构的影响。
Heterogeneous Pd-catalyzed coupling reaction of substituted halobenzenes to biphenyls is performed effectively in different organic solvents using an alcohol as the reducing agent in the presence of a base and a catalytic amount of phase-transfer (PT) agent. The alcohol is oxidized to the respective aldehyde or ketone. Kinetic studies show that the reaction rate equation fits to second order in halobenzene. The effects of reaction temperature, catalyst loading, base concentration, PTC concentration, and alcohol concentration and structure are studied and discussed.