Salivary cortisol responses in prepubertal boys: The effects of parental substance abuse and association with drug use behavior during adolescence
Salivary cortisol responses in prepubertal boys: The effects of parental substance abuse and association with drug use behavior during adolescence
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DOI：
10.1016/s0006-3223(98)00216-9
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发表时间：
1999-05-15
影响因子：
10.6
通讯作者：
Kirillova, GP
中科院分区：
文献类型：
--
作者：
Moss, HB;Vanyukov, M;Kirillova, GP
背景：本研究的目的有三个方面：首先，我们将最初观察到的物质使用障碍（SUD）父亲的儿子的皮质醇反应性降低扩展到预期的压力源；其次，我们检验了这些高风险的青春期前男孩的唾液皮质醇反应不足是对与父亲有当前而不是缓解的SUD相关的压力的适应假设。第三，我们检验了青春期前皮质醇反应不足可能与青春期随后的药物使用行为有关的假设。方法：在风险组状态、父亲药物滥用补偿和随后的青少年药物使用行为的背景下，检查青春期前唾液皮质醇反应。结果：结果证实，在我们扩大的样本中，SUD父亲的儿子对预期压力源的唾液皮质醇反应降低。此外，与对照组父亲的儿子相比，父亲目前患有SUD的儿子和父亲在3岁至6岁期间患有SUD的男孩的预期压力皮质醇水平较低。最后，较低的青春期前预期皮质醇反应与青春期期间每月定期吸烟和每月定期使用大麻有关。结论：低反应性作为对慢性应激的适应可能是药物滥用倾向代际传递的重要因素，生物精神病学1999；[45]中国生物医学杂志。
Background: The purpose of this investigation was three-fold, First, we extended our original observation of decreased cortisol reactivity to an anticipated stressor in sons of fathers with a substance use disorder (SUD), Second, we examined the hypothesis that salivary cortisol underresponsivity in these high-risk prepubertal boys is an adaptation to the stress associated with having a father with a current, rather than remitted, SUD. Third, we tested the hypothesis that prepubertal cortisol underreactivity might be associated with subsequent drug use behavior during adolescence.Methods: Preadolescent salivary cortisol responses were examined in the context of risk-group status, paternal substance abuse offsets, and subsequent adolescent drug use behavior.Results: The results confirmed a decreased salivary cortisol response to an anticipated stressor among sons of SUD fathers in our expanded sample. in addition, sons of fathers with a current SUD and boys whose fathers had a SUD offset from their 3rd to 6th birthdays had lower anticipatory stress cortisol levels compared with sons of control fathers. Finally, lower preadolescent anticipatory cortisol responses were associated with regular monthly cigarette smoking and regular monthly marijuana use during adolescence.Conclusions: Hyporeactivity as an adaptation to chronic stress may be salient to the intergenerational transmission of substance abuse liability, Biol Psychiatry 1999;45: 1293-1299 (C) 1999 Society of Biological Psychiatry.