Chemotaxis: signalling modules join hands at front and tail
Chemotaxis: signalling modules join hands at front and tail
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DOI：
10.1038/sj.embor.7400051
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发表时间：
2004-01-01
期刊：
影响因子：
7.7
通讯作者：
Van Haastert, PJM
中科院分区：
文献类型：
--
作者：
Postma, M;Bosgraaf, L;Van Haastert, PJM
趋化性是处理空间和时间信息的各种细胞内分子之间精细相互作用的结果。在这里，我们提出了一个模块化的计划之间的复杂的相互作用的前面和后面的细胞，使他们能够导航。首先，在细胞前部，活化的Rho型GTP酶诱导肌动蛋白聚合和伪足形成。第二，磷脂酰肌醇-3，4，5-三磷酸（Ptdins（3，4，5）P-3）在前缘的补丁中产生，在那里它结合含有pleckstrinhomology-domain的蛋白质，这增强了肌动蛋白的聚合和伪足的移位。第三，在Dictyosteomaamoeastrum中，已经确定了一个周期性GMP信号级联，它调节细胞后部肌球蛋白丝的形成，从而抑制可能误导细胞的侧伪足的形成。
Chemotaxis is the result of a refined interplay among various intracellular molecules that process spatial and temporal information. Here we present a modular scheme of the complex interactions between the front and the back of cells that allows them to navigate. First, at the front of the cell, activated Rho-type GTPases induce actin polymerization and pseudopod formation. Second, phosphatidylinositol-3,4,5-trisphosphate (Ptdins(3,4,5)P-3) is produced in a patch at the leading edge, where it binds pleckstrinhomology-domain-containing proteins, which enhance actin polymerization and translocation of the pseudopod. Third, in Dictyostelium amoebae, a cyclic-GMP-signalling cascade has been identified that regulates myosin filament formation in the posterior of the cell, thereby inhibiting the formation of lateral pseudopodia that could misdirect the cell.