Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
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CKIP-1 P21A 多态性与中国人群慢性心力衰竭风险的关联
DOI：
10.18632/oncotarget.16614
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发表时间：
2017-05-30
期刊：
影响因子：
--
通讯作者：
Chen XP
中科院分区：
文献类型：
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作者：
Li MP;Zhang YJ;Hu XL;Zhou JP;Yang YL;Peng LM;Qi H;Yang TL;Chen XP
病理性心脏肥大是慢性心力衰竭的独立危险因素。酪蛋白激酶2相互作用蛋白1（CKIP-1）可以抑制病理性心脏肥大。因此，我们研究了CKIP-1非同义多态性rs2306235 (Pro21Ala)是否有助于中国人群慢性心力衰竭的风险和预后。共招募了923名成年慢性心力衰竭患者和1020名年龄和性别匹配的健康对照者。使用PCR限制性片段长度多态性对CKIP-1 rs2306235多态性进行基因分型。对 140 名慢性心力衰竭患者的额外随访数据进行了评估。 rs2306235 G 等位基因与慢性心力衰竭风险增加相关（OR = 1.38，95% CI = 1.09-1.75，p = 0.007），尤其是高血压患者（OR = 1.45，95% CI = 1.09-1.75，p = 0.006）和冠心病患者（OR = 1.41，95% CI） = 1.09-1.83，p = 0.010）调整多种心血管危险因素后。然而，rs2306235 多态性与慢性心力衰竭的心血管死亡率无关（p = 0.875）。 CKIP-1 rs2306235 多态性可能是中国汉族人群慢性心力衰竭的危险因素。
Pathological cardiac hypertrophy is an independent risk factor for chronic heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) can inhibit pathological cardiac hypertrophy. Therefore, we investigated whether CKIP-1 nonsynonymous polymorphism rs2306235 (Pro21Ala) contributes to risk and prognosis of chronic heart failure in a Chinese population.A total of 923 adult patients with chronic heart failure and 1020 age- and gender-matched healthy controls were recruited. CKIP-1 rs2306235 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Additional follow-up data for 140 chronic heart failure patients was evaluated. The rs2306235 G allele was associated with an increased risk of chronic heart failure (OR = 1.38, 95% CI = 1.09-1.75, p = 0.007), especially in patients with hypertension (OR = 1.45, 95% CI = 1.09-1.75, p = 0.006) and coronary heart disease (OR = 1.41, 95% CI = 1.09-1.83, p = 0.010) after adjustment for multiple cardiovascular risk factors. However, rs2306235 polymorphism was not associated with cardiovascular mortality in chronic heart failure (p = 0.875). CKIP-1 rs2306235 polymorphism may be a risk factor for chronic heart failure in a Chinese Han population.