The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer.
The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer.
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DOI：
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发表时间：
2005-08
影响因子：
24.1
通讯作者：
Keqiang Chen;P. Iribarren;W. Gong;Jiming Wang
中科院分区：
文献类型：
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作者：
Keqiang Chen;P. Iribarren;W. Gong;Jiming Wang
Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.
