Acute locomotor responses to cocaine in adolescents vs. adults from four divergent inbred mouse strains.
Acute locomotor responses to cocaine in adolescents vs. adults from four divergent inbred mouse strains.
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四种不同近交系小鼠品系的青少年与成人对可卡因的急性运动反应。
DOI：
10.1111/j.1601-183x.2010.00630.x
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Rhodes,JS
中科院分区：
文献类型：
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作者：
Zombeck,JA;Swearingen,SP;Rhodes,JS
越来越多的证据表明，与成年小鼠相比，青春期小鼠对可卡因的急性运动激活作用表现出不同的敏感性，但差异的方向因研究而异，原因尚不清楚。很少有研究直接研究遗传因素对可卡因运动刺激的年龄差异的影响。本研究的目的是确定与成人相比，C57BL/6J 青少年的刺激减少在多大程度上普遍适用于其他菌株。因此，我们在两个年龄（出生后第 30 天和出生后第 65 天）检查了四种遗传上不同的近交染色（BALB/cByJ、C57BL/6J、DBA/2J 和 FVB/NJ）的雄性和雌性小鼠。小鼠接受盐水或可卡因（15 或 30 mg/kg），然后立即放回其家中的笼子。通过视频跟踪连续记录家中笼子的运动活动。与成年小鼠相比，青少年对 C57BL/6J、BALB/cByJ 和雌性 FVB/NJ 小鼠的刺激减少。 DBA/2J 或男性 FVB/NJ 没有观察到年龄差异。没有观察到性别的主要影响。菌株在药代动力学、神经发育或生理学方面的差异可能导致不同菌株之间观察到的年龄差异。未来的比较研究可能会发现菌株之间的生物学差异，从而解释可卡因敏感性的年龄差异。
Growing evidence suggests that adolescent mice display differential sensitivity to the acute locomotor activating effects of cocaine as compared to adults, but the direction of the difference varies across studies and the reasons are not clear. Few studies have directly examined genetic contributions to age differences in locomotor stimulation from cocaine. The goal of this study was to determine the extent to which reduced stimulation in C57BL/6J adolescents as compared to adults generalizes to other strains. Therefore, we examined male and female mice from four genetically divergent inbred stains (BALB/cByJ, C57BL/6J, DBA/2J and FVB/NJ) at two ages, postnatal day 30 and postnatal day 65. Mice received either saline or cocaine (15 or 30 mg/kg), and then immediately were placed back into their home cages. Locomotor activity was recorded continuously in the home cage by video tracking. Adolescents displayed reduced stimulation as compared to adults for C57BL/6J, BALB/cByJ and female FVB/NJ mice. No age differences were observed for DBA/2J or male FVB/NJ. No main effects of sex were observed. Strain differences in pharmacokinetics, neural development or physiology could contribute to the observed differences between ages across strains. Future comparative studies could discover biological differences between strains that explain age differences in cocaine sensitivity.