Electrical Stimulation of the Left and Right Human Fusiform Gyrus Causes Different Effects in Conscious Face Perception
Electrical Stimulation of the Left and Right Human Fusiform Gyrus Causes Different Effects in Conscious Face Perception
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DOI：
10.1523/jneurosci.0527-14.2014
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发表时间：
2014-09-17
影响因子：
5.3
通讯作者：
Parvizi, Josef
中科院分区：
文献类型：
--
作者：
Rangarajan, Vinitha;Hermes, Dora;Parvizi, Josef
跨物种的神经影像学和电生理研究证实了双侧颞腹皮层（VTC）的面部选择反应，并且在VTC包括梭状回（FG）病变的患者中报告了面孔失认症。由于成像和电生理研究提供了相关的证据，并且脑损伤通常包括脑前皮层以外的白质和灰质结构，我们设计了当前的研究，以探索脑后皮层中与面部相关的电生理反应与电刺激左或右脑后皮层对面部感知的因果效应之间的联系。我们将皮质电图（ECoG）和脑电刺激（EBS）相结合，对10名受试者在左半球（5名受试者，30个FG位点）或右半球（5名受试者，26个FG位点）植入颅内电极。我们确定了具有面部选择性ECoG反应的FG位点，并在EBS期间记录了这些位点的感知报告。与现有文献一致，左侧和右侧FG位点均存在面部选择性ECoG反应。然而，当相同的部位受到刺激时，我们观察到两个半球之间的显著差异。只有右侧FG的EBS引起了对面孔的有意识感知的变化，而左侧FG强烈的面部选择区域的EBS产生了与面孔无关的视觉变化，如幻视。本研究分别考察了脑电信号和脑电信号的相关与因果关系，并对左右脑电信号在有意识面部知觉中的不同作用提供了重要的见解。
Neuroimaging and electrophysiological studies across species have confirmed bilateral face-selective responses in the ventral temporal cortex (VTC) and prosopagnosia is reported in patients with lesions in the VTC including the fusiform gyrus (FG). As imaging and electrophysiological studies provide correlative evidence, and brain lesions often comprise both white and gray matter structures beyond the FG, we designed the current study to explore the link between face-related electrophysiological responses in the FG and the causal effects of electrical stimulation of the left or right FG in face perception. We used a combination of electrocorticography (ECoG) and electrical brain stimulation (EBS) in 10 human subjects implanted with intracranial electrodes in either the left (5 participants, 30 FG sites) or right (5 participants, 26 FG sites) hemispheres. We identified FG sites with face-selective ECoG responses, and recorded perceptual reports during EBS of these sites. In line with existing literature, face-selective ECoG responses were present in both left and right FG sites. However, when the same sites were stimulated, we observed a striking difference between hemispheres. Only EBS of the right FG caused changes in the conscious perception of faces, whereas EBS of strongly face-selective regions in the left FG produced non-face-related visual changes, such as phosphenes. This study examines the relationship between correlative versus causal nature of ECoG and EBS, respectively, and provides important insight into the differential roles of the right versus left FG in conscious face perception.