Sexually Transmitted Infection Among Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder: A Nationwide Longitudinal Study
Sexually Transmitted Infection Among Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder: A Nationwide Longitudinal Study
复制标题
DOI：
10.1016/j.jaac.2017.09.438
复制
发表时间：
2018-01-01
影响因子：
13.3
通讯作者：
Chen, Tzeng-Ji
中科院分区：
文献类型：
--
作者：
Chen, Mu-Hong;Hsu, Ju-Wei;Chen, Tzeng-Ji
目的：注意力缺陷多动障碍（attention deficit/hyperactivity disorder，ADHD）与危险性行为有关，危险性行为被认为是性传播感染（sexually transmitted infection，STI）的主要危险因素。然而，ADHD和随后的STIs之间的关联仍然未知。方法：使用台湾国民健康保险研究数据库，17,898名青少年和年轻人谁被诊断为ADHD的精神科医生和71,592年龄和性别匹配的比较没有ADHD从2001年至2009年，并跟踪到2011年底。确定了在随访期间发生任何STI的参与者。考克斯回归分析进行检查的风险与ADHD患者和那些没有ADHDM.Results：ADHD患者容易发展任何STI（风险比[FIR] 3.36，95%CI 2.69类似于4.21）调整后的人口统计学数据，精神科合并症，ADHD药物与对照组相比。物质使用障碍（HR 1.94，95% CI 1.27，类似于2.98）也与STI风险相关。ADHD药物的短期使用（HR 0.70，95% CI 0.53，类似于0.94）和长期使用（HR 0.59，95% CI 0.37，类似于0.93）与后续STI的风险较低相关。然而，仅在妇女中观察到物质使用障碍与性传播感染之间的关联。相比之下，ADHD药物治疗的STI风险降低的效果，观察到只有在manifest.Conclusion：青少年和年轻的成年人与ADHD有一个增加的风险发展任何STI以后的生活相比，非ADHD的比较。患有ADHD的患者如果同时患有物质使用障碍，则其随后发生性传播感染的风险最高。ADHD药物治疗与随后性传播感染的风险较低相关。
Objective: Previous studies have suKested that attention-deficit/hyperactivity disorder (ADHD) is related to risky sexual behaviors, which have been regarded as a major risk factor of sexually transmitted infection (STI). However, the association between ADHD and subsequent STIs remains unknown.Method: Using the Taiwan National Health Insurance Research Database, 17,898 adolescents and young adults who were diagnosed with ADHD by psychiatrists and 71,592 age- and sex-matched comparisons without ADHD were enrolled from 2001 through 2009 and followed to the end of 2011. Participants who developed any STI during the follow-up period were identified. Cox regression analysis was performed to examine the risk of STIs between patients with ADHD and those without ADHD.Results: Patients with ADHD were prone to developing any STI (hazard ratio [FIR] 3.36, 95% CI 2.69 similar to 4.21) after adjusting for demographic data, psychiatric comorbidities, and ADHD medications compared with the comparison group. Substance use disorders (HR 1.94, 95% CI 1.27 similar to 2.98) also were associated with STI risk. Short-term use (HR 0.70, 95% CI 0.53 similar to 0.94) and long-term use (HR 0.59, 95% CI 0.37 similar to 0.93) of ADHD medications were related to a lower risk of subsequent STIs. However, an association between substance use disorders and STIs was observed only in women. By contrast, the effect of ADHD medications on the decrease of STI risk was observed only in men.Conclusion: Adolescents and young adults with ADHD had an increased risk of developing any STI later in life compared with the non-ADHD comparisons. Patients with ADHD who also had substance use disorders were at the highest risk of subsequent STIs. Treatment with ADHD medications was associated with a lower risk of subsequent STIs.