Effects of estrogens on macrophage foam cells: a potential target for the protective effects of estrogens on atherosclerosis.
Effects of estrogens on macrophage foam cells: a potential target for the protective effects of estrogens on atherosclerosis.
复制标题
雌激素对巨噬细胞泡沫细胞的影响：雌激素对动脉粥样硬化保护作用的潜在目标。
DOI：
10.1097/00041433-199710000-00007
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发表时间：
1997
影响因子：
4.4
通讯作者：
StClair,RW
中科院分区：
文献类型：
--
作者：
StClair,RW
雌激素在人类和几种动物模型中显示出显著减少动脉粥样硬化的发展。超过50%的这种效应似乎是由对动脉壁的直接作用引起的。虽然雌激素可以影响内皮细胞和平滑肌细胞的多种功能，但过去几年发表的数据表明，巨噬细胞泡沫细胞也可能是雌激素作用的重要部位。本文就雌激素对巨噬细胞泡沫细胞功能影响的研究进展作一综述。这些数据表明，雌激素以几种方式减少巨噬细胞中胆固醇酯的积累。
Estrogens have been shown to reduce markedly the development of atherosclerosis in humans and in several animal models. More than 50% of this effect appears to be caused by a direct action on the arterial wall. Although estrogens can affect a variety of functions of endothelial cells and smooth muscle cells, data published over the past few years suggest that macrophage foam cells may also be an important site of estrogen action. This review summarizes the recent data on the effects of estrogens on macrophage foam cell function. The data suggest that estrogens act in several ways to reduce the accumulation of cholesteryl esters in macrophages.