Prevalence of age-related macular degeneration in the United States.
Prevalence of age-related macular degeneration in the United States.
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DOI：
10.1001/archopht.122.4.564
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发表时间：
2004-04
影响因子：
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通讯作者：
David S. Friedman;Benita J. O’Colmain;Beatriz Muñoz;S. Tomany;Cathy McCarty;Paulus T. V. M. de Jong
中科院分区：
文献类型：
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作者：
David S. Friedman;Benita J. O’Colmain;Beatriz Muñoz;S. Tomany;Cathy McCarty;Paulus T. V. M. de Jong
目的评估美国年龄相关性黄斑变性（AMD）的患病率和分布，包括年龄、种族/民族和性别。方法：对黑人和白色人从40岁开始的5年年龄间隔中125 microm或更大玻璃疣、新生血管性AMD和地图状萎缩的患病率进行了总结。估计的发生率是基于最近在美国、澳大利亚和欧洲进行的基于人群的研究的荟萃分析。将这些比率应用于2000年美国人口普查数据和2020年预计的美国人口数字，以估计玻璃疣和AMD的美国人口数量。结果：在美国40岁及以上人群中，新生血管性AMD和/或地图状萎缩的总体患病率估计为1.47%（95%置信区间，1.38%-1.55%），有175万公民患有AMD。AMD的患病率随着年龄的增长而显著增加，超过15%的80岁以上的白色女性患有新生血管性AMD和/或地图状萎缩。超过700万人有玻璃疣测量125微米或更大，因此，在发展为AMD的巨大风险。由于人口迅速老龄化，到2020年，AMD患者人数将增加50%至295万人。视网膜相关性黄斑变性在白色人群中的患病率远高于黑人。在美国，视网膜相关性黄斑变性影响超过175万人。由于美国人口的迅速老龄化，到2020年，这一数字将增加到近300万。
OBJECTIVE To estimate the prevalence and distribution of age-related macular degeneration (AMD) in the United States by age, race/ethnicity, and gender. METHODS Summary prevalence estimates of drusen 125 microm or larger, neovascular AMD, and geographic atrophy were prepared separately for black and white persons in 5-year age intervals starting at 40 years. The estimated rates were based on a meta-analysis of recent population-based studies in the United States, Australia, and Europe. These rates were applied to 2000 US Census data and to projected US population figures for 2020 to estimate the number of the US population with drusen and AMD. RESULTS The overall prevalence of neovascular AMD and/or geographic atrophy in the US population 40 years and older is estimated to be 1.47% (95% confidence interval, 1.38%-1.55%), with 1.75 million citizens having AMD. The prevalence of AMD increased dramatically with age, with more than 15% of the white women older than 80 years having neovascular AMD and/or geographic atrophy. More than 7 million individuals had drusen measuring 125 microm or larger and were, therefore, at substantial risk of developing AMD. Owing to the rapidly aging population, the number of persons having AMD will increase by 50% to 2.95 million in 2020. Age-related macular degeneration was far more prevalent among white than among black persons. CONCLUSION Age-related macular degeneration affects more than 1.75 million individuals in the United States. Owing to the rapid aging of the US population, this number will increase to almost 3 million by 2020.