MATERNAL AGING AND ANEUPLOID EMBRYOS - EVIDENCE FROM THE MOUSE THAT BIOLOGICAL AND NOT CHRONOLOGICAL AGE IS THE IMPORTANT INFLUENCE
MATERNAL AGING AND ANEUPLOID EMBRYOS - EVIDENCE FROM THE MOUSE THAT BIOLOGICAL AND NOT CHRONOLOGICAL AGE IS THE IMPORTANT INFLUENCE
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DOI：
10.1007/bf00275184
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发表时间：
1984-01-01
期刊：
影响因子：
5.3
通讯作者：
CHANDLEY, AC
中科院分区：
文献类型：
--
作者：
BROOK, JD;GOSDEN, RG;CHANDLEY, AC
在人类非整倍体的病因中，母体老化仍然是压倒性的因素。卵母细胞中异常的减数分裂染色体分离是与卵巢生理性衰老有关，还是与某些依赖于时间推移的因素有关，仍有待确定。目前在小鼠身上的实验研究表明是前者。CBA女性单侧卵巢切除导致的生殖生活提前终止，导致不规则周期的出现和非整倍体的提前上升。这一结果不能用生产线假说来解释。其临床意义是，怀孕唐氏胎儿的可能性将由即将到来的更年期的时间距离决定，而不是由妇女本身的实际年龄决定。
Maternal aging remains the overwhelming factor in the etiology of human aneuploidy. Whether aberrant meiotic chromosome segregation in the oocyte relates causally to ovarian physiological aging or to some factor dependent on the passage of chronological time, remains to be determined. The present experimental studies in the mouse indicate the former. An earlier cessation of reproductive life, brought on by unilateral ovariectomy in CBA females, resulted in the earlier onset of irregular cyclicity and an earlier rise in aneuploidy. The results could not be explained on the basis of the production line hypothesis. The clinical implications are that the probability of conceiving a Down fetus will be determined by distnce in time from the approaching menopause, rather than by the chronological age of the woman per se.