Tumor necrosis factor-α and interferon-γ polymorphisms contribute to susceptibility to oral lichen planus
Tumor necrosis factor-α and interferon-γ polymorphisms contribute to susceptibility to oral lichen planus
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DOI：
10.1046/j.0022-202x.2003.22108.x
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发表时间：
2004-01-01
影响因子：
6.5
通讯作者：
Gandolfo, S
中科院分区：
文献类型：
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作者：
Carrozzo, M;de Capei, MU;Gandolfo, S
口腔扁平苔藓(OLP)皮损固有层中的大多数淋巴细胞表达和分泌干扰素-γ(IFN-γ)和肿瘤坏死因子-α(TNF-α)，而不分泌IL-4和-10或转化生长因子-β。我们分析了几种细胞因子的多态性是否会影响OLP的易感性。采用序列特异性聚合酶链式反应进行细胞因子分型。研究对象为13个细胞因子基因，共22个单核苷酸多态性。与对照组相比，口腔扁平苔藓组T/T纯合子数量显著增加(40.9%vs22.9%；p=0.0022)。此外，口腔扁平苔藓患者中-308a等位基因频率明显高于对照组(21.6%vs.9.3%；P
Most lymphocytes in the lamina propria of oral lichen planus (OLP) lesions express and secrete interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), whereas they do not secret interleukin-4 and -10 or transforming growth factor-beta. We analyzed whether the polymorphisms of several cytokines may influence the susceptibility to OLP. Cytokine typing was performed by a sequence-specific PCR assay. Thirteen cytokine genes with 22 single-nucleotide polymorphisms were studied. IFN-gamma UTR 5644 genotype frequencies showed a significant increase in number of T/T homozygotes in OLP patients compared with controls (40.9 vs. 22.9%; p=0.0022). Moreover, in OLP patients, the frequency of the -308A TNF-alpha allele was higher than in the controls (21.6 vs. 9.3%; p