Comparison of 2D reconstructions of surgically excised subfoveal choroidal neovascularization with fluorescein angiographic features: SST report No. 15.
Comparison of 2D reconstructions of surgically excised subfoveal choroidal neovascularization with fluorescein angiographic features: SST report No. 15.
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手术切除的中心凹下脉络膜新生血管的二维重建与荧光素血管造影特征的比较：SST 报告第 15 号。
DOI：
10.1016/j.ophtha.2005.10.031
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发表时间：
2006
期刊：
影响因子：
13.7
通讯作者：
SubmacularSurgeryTrialsResearchGroup
中科院分区：
文献类型：
--
作者：
SubmacularSurgeryTrialsResearchGroup
目的比较手术切除的黄斑下脉络膜新生血管的地形图特征与来自黄斑下手术试验（SST）患者的术前和术后荧光素血管造影特征，并比较组织学和血管造影特征与术前和术后视力（VA）。1999年10月至2001年9月之间进行的和H试验，并分配到手术组，手术切除了送往SST病理学中心的脉络膜新生血管。将大体完整的标本连续切片进行二维重建，并根据细胞组分相对于视网膜色素上皮（RPE）的位置的地形图将其分配至生长模式组：RPE下、视网膜下、组合或不确定。这些特征与术前荧光素血管造影特征进行比较。组织学脉络膜新生血管的生长模式与术前VAS. WoTSTwo-dimensional重建手术切除的脉络膜新生血管不能匹配点荧光血管造影功能点。在所选的52个标本中，34例（65%）可通过二维重建确定生长模式，包括35个N组标本中的28例（80%）、5个B组标本中的2例（40%）和12个H组标本中的4例（33%）。在可从提交的标本中确定的脉络膜新生血管生长模式中，大多数N组标本合并，大多数H组标本为视网膜下。在大多数情况下，B组标本的生长模式不确定。荧光素血管造影的术后异常通常大于切除标本的测量值。视网膜下生长模式与术后3个月平均VA的最小下降相关。CONCLUSIONSAmong的52个标本从SST有足够的组织，试图评估新生血管病变的生长模式，34模式，可以确定。视网膜下生长模式倾向于与荧光素血管造影显示的典型脉络膜新生血管病变相对应，而无隐匿性脉络膜新生血管病变。如果脉络膜新生血管具有视网膜下生长模式，则出现最有利的视力结果。合并的生长模式往往与荧光素血管造影显示的既有典型脉络膜新生血管又有隐匿性脉络膜新生血管的病变相对应。必须在52名参与者中有18名（35%）无法描述组织学生长模式的背景下看待结论。
OBJECTIVESTo compare topographic features of surgically excised subfoveal choroidal neovascularization with preoperative and postoperative fluorescein angiographic features from Submacular Surgery Trials (SST) patients, and to compare histological and angiographic features with preoperative and postoperative visual acuities (VAs).METHODSPatients enrolled in the SST Groups N, B, and H trials between October 1999 and September 2001 and assigned to the surgery arm had surgically removed choroidal neovascularization sent to the SST Pathology Center. Grossly intact specimens were sectioned serially for 2-dimensional reconstruction and were assigned to growth pattern groups based on topographic mapping of the location of cellular components relative to the retinal pigment epithelium (RPE): sub-RPE, subretinal, combined, or indeterminate. These features were compared with preoperative fluorescein angiographic features. The histological choroidal neovascularization growth pattern was compared with preoperative VAs.RESULTSTwo-dimensional reconstructions of surgically excised choroidal neovascularization could not be matched point for point to fluorescein angiographic features. Among the 52 specimens selected, the growth pattern could be determined by 2-dimensional reconstruction in 34 instances (65%), including 28 (80%) of 35 Group N specimens, 2 (40%) of 5 Group B specimens, and 4 (33%) of 12 Group H specimens. Among the choroidal neovascularization growth patterns that could be determined from specimens submitted, the majority of Group N specimens were combined, and the majority of Group H specimens were subretinal. In most instances for Group B specimens, the growth pattern was indeterminate. The postoperative abnormalities on fluorescein angiography were generally larger than measurements of excised specimens. The subretinal growth pattern was associated with the smallest decrease in 3-month postoperative average VA.CONCLUSIONSAmong the 52 specimens from the SST with adequate tissue to try to evaluate the growth pattern of the neovascular lesion, 34 had patterns that could be determined. The subretinal growth pattern tended to correspond with lesions that were classic choroidal neovascularization without occult choroidal neovascularization on fluorescein angiography. The most favorable visual outcome occurred if the choroidal neovascularization had a subretinal growth pattern. The combined growth pattern tended to correspond with lesions on fluorescein angiography that had both classic choroidal neovascularization and occult choroidal neovascularization. The conclusions must be viewed within the context that 18 (35%) of the 52 participants could not be characterized for histologic growth pattern.