Suppression of experimental antigen-induced arthritis in transgenic mice producing human alpha-fetoprotein.
Suppression of experimental antigen-induced arthritis in transgenic mice producing human alpha-fetoprotein.
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在产生人甲胎蛋白的转基因小鼠中抑制实验性抗原诱导的关节炎。
DOI：
10.1006/bbrc.1995.2138
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发表时间：
1995
影响因子：
3.1
通讯作者：
S. Nishi
中科院分区：
文献类型：
--
作者：
A. Ogata;T. Yamashita;Y. Koyama;M. Sakai;S. Nishi
通过用弗氏完全佐剂中的甲基化牛血清白蛋白免疫表达人甲胎蛋白的转基因小鼠，在膝关节中诱导实验性关节炎。在正常C57 BL/6小鼠的对照实验中，55.6%（5/9）的小鼠观察到明确的关节炎，而转基因小鼠仅21.1%（4/19）。这一结果表明，人甲胎蛋白作为一种免疫抑制剂，以改善免疫性疾病的发展。
Experimental arthritis was induced in the knee joint of transgenic mice expressing human alpha-fetoprotein by immunization with methylated bovine serum albumin in Freund's complete adjuvant. In the control experiment with normal C57BL/6 mice, definite arthritis was observed in 55.6% (5/9) of the mice, but in only 21.1% (4/19) of the transgenic mice. This result suggested that human alpha-fetoprotein functioned as an immunosuppressant to ameliorate the development of the immune disease.