Antibiotic Action and Peptidoglycan Formation on Tethered Lipid Bilayer Membranes
Antibiotic Action and Peptidoglycan Formation on Tethered Lipid Bilayer Membranes
复制标题
束缚脂质双层膜上的抗生素作用和肽聚糖形成
DOI：
10.1002/ange.200504035
复制
发表时间：
2006
影响因子：
--
通讯作者：
Spencelayh M
中科院分区：
文献类型：
--
作者：
Spencelayh M
The inner-bilayer membranes of Gram-positive bacteria are surrounded by a layer of peptidoglycan, in the form of a polymer net, which serves to provide mechanical support against lysis due to osmotic stress. Prevention of peptidoglycan formation makes bacterial cells prone to lysis and represents one of the three main mechanisms of antibiotic action; the others being inhibition of protein synthesis and the inhibition of RNA/DNA synthesis.[1] Vancomycin has been a mainstay of the glycopeptide antibiotics and is active against a wide range of Gram-positive bacteria. However, the emergence of widespread resistance amongst pathogenic bacteria has highlighted the need for new and effective antibacterial compounds, and consequently there has been a significant effort devoted to understanding the mechanisms of antibiotic action and resistance.[2a–e]Most studies performed, to date, on understanding the structure–function relationship involved in antibiotic interaction with peptidoglycan precursors have focused on the use of micelles, vesicles, and soluble precursors. Although important information has been gained from such studies, there are drawbacks in that either they do not represent a close mimic of the in vivo situation or, in the case of vesicles, they are not amenable to study by using the array of surface-science techniques currently available. In 1997, Williams et al. formed
