Association between genital schistosomiasis and HIV in rural Zimbabwean women
Association between genital schistosomiasis and HIV in rural Zimbabwean women
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DOI：
10.1097/01.aids.0000210614.45212.0a
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发表时间：
2006-02-28
期刊：
影响因子：
3.8
通讯作者：
Gundersen, SG
中科院分区：
文献类型：
--
作者：
Kjetland, EF;Ndhlovu, PD;Gundersen, SG
目的：探讨女性生殖器血吸虫感染与人类免疫缺陷病毒(HIV)感染的关系。设计与方法：一项横断面研究，随访1年。对血瘤链球菌和艾滋病毒进行了妇科和实验室调查。性传播感染、人口统计学和泌尿生殖器病史被分析为混杂因素。参与者是527名年龄在20岁至49岁之间的性活跃、未怀孕、未绝经的女性。结果：在常住居民中，41%(29/70)的女性患有实验室确诊的生殖器血吸虫病，而在血吸虫卵子阴性组中，26%(96/375)的女性感染了HIV[优势比(OR)2.1；95%可信区间(CI)1.2-3.5；P=0.008]。在多因素分析中，生殖器粘膜血吸虫感染与HIV血清阳性显著相关(校正OR2.9；95%CI1.11~7.5P=0.030)。在研究期间艾滋病毒呈阳性的所有7名妇女(血清发病率3.1%)在基线时都有血瘤葡萄球菌的迹象。根据其他研究，艾滋病毒与单纯疱疹病毒2型(OR3.0；95%CI，1.7-5.3；P<；0.001)、梅毒和人乳头瘤病毒显著相关。结论：在津巴布韦农村地区，生殖器血吸虫病妇女感染艾滋病毒的风险几乎是前者的三倍。需要前瞻性研究来证实这种联系。(C)2006年，Lippincott Williams&Wilkins。
Objective: To determine the association between female genital Schistosoma haematobium infection and HIV.Design and methods: A cross-sectional study with a 1-year follow-up. Gynecological and laboratory investigations were performed for S. haematobium and HIV. Sexually transmitted infections, demographic and urogenital history were analysed as confounders. The participants were 527 sexually active, non-pregnant, non-menopausal women between the ages of 20 and 49 years. The setting was a rural Zimbabwean community where S. haematobium related lesions were found in 46% of the women, HIV in 29% and herpes simplex type-2 (HSV-2) in 65%.Results: In permanent residents (>3 years residency), HIV was found in 41% (29/70) of women with laboratory proven genital schistosomiasis as opposed to 26% HIV positive (96/375) in the schistosomal ova negative group [odds ratio (OR), 2.1; 95% confidence interval (CI), 1.2-3.5; P = 0.008. In multivariate analysis S. haematobium infection of the genital mucosa was significantly associated with HIV seropositivity (adjusted OR, 2.9; 95% CI, 1.11-7.5; P = 0.030). All seven women who became HIV positive during the study period (seroincidence 3.1%) had signs of S. haematobium at baseline. In accordance with other studies HIV was significantly associated with HSV-2 (OR, 3.0; 95% CI, 1.7-5.3; P < 0.001), syphilis and human papillomavirus. The highest HIV prevalence (45%) was found in the 25-29 years age group.Conclusion: Women with genital schistosomiasis had an almost three-fold risk of having HIV in this rural Zimbabwean community. Prospective studies are needed to confirm the association. (C) 2006 Lippincott Williams & Wilkins.