INHIBITION OF GASTRIC-EMPTYING AND DRUG ABSORPTION BY NARCOTIC ANALGESICS
INHIBITION OF GASTRIC-EMPTYING AND DRUG ABSORPTION BY NARCOTIC ANALGESICS
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DOI：
10.1111/j.1365-2125.1975.tb00568.x
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发表时间：
1975-01-01
影响因子：
3.4
通讯作者：
PRESCOTT, LF
中科院分区：
文献类型：
--
作者：
NIMMO, WS;HEADING, RC;PRESCOTT, LF
在8名正常受试者中评估了肌肉注射哌替啶或二乙酰吗啡对胃排空和口服对乙酰氨基酚吸收的影响。2两种药物均显著延迟对乙酰氨基酚的胃排空和吸收。哌替啶和二乙酰吗啡似乎不可避免地会阻碍其他口服药物的吸收。
The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.