Effect of lifetime lactation on breast cancer risk: A Korean women's cohort study
Effect of lifetime lactation on breast cancer risk: A Korean women's cohort study
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DOI：
10.1002/ijc.11078
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发表时间：
2003-06-20
影响因子：
6.4
通讯作者：
Yoon, SJ
中科院分区：
文献类型：
--
作者：
Lee, SY;Kim, MT;Yoon, SJ
本研究的目的是探讨绝经前妇女一生中哺乳期对乳腺癌风险的影响。数据来自韩国一项随访6年的前瞻性队列研究（1995-2000）。该队列由110,604名20岁及以上的绝经前韩国妇女组成，她们从韩国医疗保险公司获得健康保险，并在1992年和1994年进行了医疗评估。检验多变量Cox比例风险模型，控制年龄、初潮年龄、子女数量、首次怀孕年龄、口服避孕药使用、吸烟、运动和肥胖。基线时，57,440名（51.9%）报告母乳喂养，4,584名（4.1%）报告母乳喂养超过24个月。从1995年到2000年，发生了360例乳腺癌（61.8/10万人年）。与没有哺乳史的产妇相比，哺乳期为13-24个月的妇女患乳腺癌的风险降低（相对危险度，0.7;95% CI, 0.5-1.1），母乳喂养超过24个月的妇女患乳腺癌的风险进一步降低（相对危险度，0.6;95% CI, 0.3-1.0）。随着哺乳时间的延长，乳腺癌风险有明显的降低趋势（p为趋势）
The objective of our study was to examine the effect of lifetime lactation on breast cancer risk among premenopausal women. The data were from a prospective cohort study with a follow-up period of 6 years in Korea (1995-2000). The cohort was composed of 110,604 premenopausal parous Korean women, aged 20 years and older, who received health insurance from the Korea Medical Insurance Corporation and who had medical evaluations in 1992 and 1994. Multivariate Cox proportional hazard models were tested, controlling for age, age at menarche, number of children, age at first pregnancy, oral contraceptive use, smoking, exercise and obesity. At baseline, 57,440 (51.9%) reported breastfeeding and 4,584 (4.1%) reported breastfeeding more than 24 months. From 1995-2000, 360 incident cases of breast cancer (61.8/100,000 person-years) occurred. Compared to parous women who had no history of lactation, a period of lactation of 13-24 months decreased the risk of breast cancer (RR, 0.7; 95% CI, 0.5-1.1), and this risk was decreased even further for those who breastfed for more than 24 months (RR, 0.6; 95% CI, 0.3-1.0). There was a clear trend of decreasing breast cancer risk with the duration of lactation (p for trend