The Complex Interaction of Matrix Metalloproteinases in the Migration of Cancer Cells through Breast Tissue Stroma.
The Complex Interaction of Matrix Metalloproteinases in the Migration of Cancer Cells through Breast Tissue Stroma.
复制标题
DOI：
10.1155/2014/839094
复制
发表时间：
2014
影响因子：
1.9
通讯作者：
Davies KJ
中科院分区：
文献类型：
--
作者：
Davies KJ
乳腺癌死亡率与转移扩散直接相关。转移性细胞必须表现出复杂的表型，其包括从原发性肿瘤块逃逸、侵入周围正常组织并在远处器官的实质中增殖以产生转移之前渗透到循环中的能力。在正常乳腺中，细胞结构响应于卵巢激素而周期性地变化，从而导致受调节的细胞增殖和凋亡。基质金属蛋白酶（MMPs）是锌依赖性内肽酶家族。其主要功能是降解细胞外基质中的蛋白质，以允许导管通过基底膜前进。基质金属蛋白酶及其抑制剂之间的复杂平衡调节这些变化。这些蛋白酶与细胞因子、生长因子和肿瘤坏死因子相互作用以刺激正常乳腺组织中的分支形态。在乳腺癌中，这一过程被破坏，促进肿瘤进展和转移，并抑制细胞凋亡，增加转移细胞的寿命。本文着重介绍了基质金属蛋白酶在乳腺间质细胞进展中的作用，并回顾了不同蛋白酶及其抑制剂与乳腺癌细胞转移之间的复杂关系。
Breast cancer mortality is directly linked to metastatic spread. The metastatic cell must exhibit a complex phenotype that includes the capacity to escape from the primary tumour mass, invade the surrounding normal tissue, and penetrate into the circulation before proliferating in the parenchyma of distant organs to produce a metastasis. In the normal breast, cellular structures change cyclically in response to ovarian hormones leading to regulated cell proliferation and apoptosis. Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix to allow ductal progression through the basement membrane. A complex balance between matrix metalloproteinases and their inhibitors regulate these changes. These proteinases interact with cytokines, growth factors, and tumour necrosis factors to stimulate branching morphologies in normal breast tissues. In breast cancer this process is disrupted facilitating tumour progression and metastasis and inhibiting apoptosis increasing the life of the metastatic cells. This paper highlights the role of matrix metalloproteinases in cell progression through the breast stroma and reviews the complex relationships between the different proteinases and their inhibitors in relation to breast cancer cells as they metastasise.