The effect of increasing age on the risk of surgical site infection
The effect of increasing age on the risk of surgical site infection
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DOI：
10.1086/428626
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发表时间：
2005-04-01
影响因子：
6.4
通讯作者：
Schmader, KE
中科院分区：
文献类型：
--
作者：
Kaye, KS;Schmit, K;Schmader, KE
背景越来越多的老年人接受手术，但年龄增加与手术部位感染（SSI）风险之间的关系尚未确定。本研究的目的是确定年龄增长与SSI风险之间的关系。本队列研究纳入了1991年2月至2002年7月期间接受手术的患者。年龄117岁的患者被随机分为推导和验证队列。该研究在11家医院进行。根据疾病控制和预防中心的标准前瞻性地确定SSI。该研究包括144，485例连续手术患者和1684例SSI（SSI发生率，1.2%）。衍生队列中有72，139例手术和873例SSI。调整后的分析显示，年龄与SSI风险之间存在显著关系（）。SSI的风险在17岁至65岁之间每年增加1.1%（Pp。006 Pp）。在年龄大于或等于65岁时，SSI的风险每增加一年下降1.2%（P = 0.008）。确认队列中有72，334例手术和811例SSI。年龄与SSI风险之间的关系在验证队列中相似。年龄增加独立预测SSI风险增加，直至65岁。在年龄大于或等于65岁时，年龄增加独立预测SSI风险降低。
Background. An increasing number of older persons undergo surgery, but the relationship between increasing age and risk of surgical site infection (SSI) has not been established. The objective of the present study was to determine the relationship between increasing age and risk of SSI.Methods. The present cohort study included patients who underwent surgery between February 1991 and July 2002. Patients 117 years of age were divided randomly into derivation and validation cohorts. The study was conducted at 11 hospitals. SSIs were prospectively identified by use of Centers for Disease Control and Prevention criteria.Results. The study included 144,485 consecutive surgical patients and 1684 SSIs ( rate of SSI, 1.2%). There were 72,139 procedures and 873 SSIs in the derivation cohort. Adjusted analyses revealed a significant relationship between age and risk of SSI (). Risk of SSI increased by 1.1%/ year between ages 17 and 65 years ( Pp. 006 Pp). At age greater than or equal to 65 years, risk of SSI decreased by 1.2% for each additional year (P = .008). There were 72,334 procedures and 811 SSIs in the validation cohort. The relationship between age and risk of SSI was similar in the validation cohort.Conclusions. Increasing age independently predicted an increased risk of SSI until age 65 years. At ages greater than or equal to 65 years, increasing age independently predicted a decreased risk of SSI.