Subpopulations of human peripheral granulocyes and monocytes express receptors for IgA.
Subpopulations of human peripheral granulocyes and monocytes express receptors for IgA.
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人类外周粒细胞和单核细胞亚群表达 IgA 受体。
DOI：
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发表时间：
1980
影响因子：
11.1
通讯作者：
G. Bernier
中科院分区：
文献类型：
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作者：
M. Fanger;L. Shen;J. Pugh;G. Bernier
通过用兔 IgG、IgA 和 IgM 致敏的牛红细胞形成玫瑰花结来计数人外周血细胞上免疫球蛋白 Fc 部分的受体。发现大部分纯化的多形核白细胞和单核细胞表达 IgA 受体。还发现这些受体存在于比之前观察到的显着更高百分比的淋巴细胞上。 IgA 受体是特异性的，通过使用纯化的人免疫球蛋白的阻断研究证实了这一点。此外，还观察到一些多形核白细胞和单核细胞同时拥有 IgG 和 IgA 的独立受体。这些研究可能表明，IgA 可以通过单核细胞或多形核白细胞上的 IgA 受体与这些细胞合作，并可能介导粘膜表面的免疫防御。对抗体依赖性细胞毒性的初步研究表明，单独的 IgA 无法有效支持未活化的人外周血细胞的细胞溶解作用。
Receptors for the Fc portion of immunoglobin on human peripheral blood cells were enumerated by rosette formation with ox erythrocytes sensitized with rabbit IgG, IgA, and IgM. A large percentage of purified polymorphonuclear leukocytes and monocytes were found to express receptors for IgA. These receptors were also found to exist on a significantly greater percentage of lymphocytes than was previously observed. The receptors for IgA were specific, as verified by blocking studies using purified human immunogloblins. In addition, some polymorphonuclear leukocytes and monocytes were observed concomitantly to posses independent receptors for both IgG and IgA. These studies may indicate that IgA can cooperate with monocytes or polymorphonuclear leukocytes through receptors for IgA on these cells and perhaps mediate immune defense on mucosal surfaces. Initial studies on antibody-dependent cellular cytotoxicity suggested that IgA alone is ineffectual in supporting cytolysis by nonactivated human peripheral blood cells.