WELL-DIFFERENTIATED THYMIC CARCINOMA - AN ORGANOTYPICAL LOW-GRADE CARCINOMA WITH RELATIONSHIP TO CORTICAL THYMOMA
WELL-DIFFERENTIATED THYMIC CARCINOMA - AN ORGANOTYPICAL LOW-GRADE CARCINOMA WITH RELATIONSHIP TO CORTICAL THYMOMA
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DOI：
10.1097/00000478-199212000-00003
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发表时间：
1992-12-01
影响因子：
5.6
通讯作者：
MULLERHERMELINK, HK
中科院分区：
文献类型：
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作者：
KIRCHNER, T;SCHALKE, B;MULLERHERMELINK, HK
根据对 26 例病例的研究，高分化胸腺癌被描述为一种独特的器官型胸腺癌，具有低度恶性。其特征是上皮细胞占优势，有丝分裂率通常较低，表皮样分化具有轻微至中度的细胞学异型性，上皮间未成熟皮质胸腺细胞持续存在，小叶生长，以及血管周围空间周围上皮栅栏的形成。男性和女性的肿瘤发生年龄为 14 至 76 岁。 77%的患者伴有重症肌无力，83%的肿瘤在初次手术时表现出邻近器官的侵犯或胸腔内转移。该比率高于皮质胸腺瘤 (47%)，但低于其他胸腺癌 (92%)。随访18例患者中有2例因肿瘤复发和胸膜转移死亡。高分化胸腺癌可能与皮质胸腺瘤具有共同的形态特征和相似的上皮细胞免疫表型。它必须与皮质类固醇治疗后淋巴细胞耗尽的皮质胸腺瘤和良性富含上皮的髓质胸腺瘤相鉴别。
Based on a study of 26 cases, the well-differentiated thymic carcinoma is described as a distinct organotypical carcinoma of the thymus with low-grade malignancy. It is characterized by a predominance of epithelial cells with usually low mitotic rate, an epidermoid differentiation with slight to moderate cytological atypia, the constant presence of interepithelial immature cortical thymocytes, lobular growth, and formation of epithelial palisades around perivascular spaces. The tumor occurs at age 14 to 76 years in both sexes. An association with myasthenia gravis is found in 77% of the patients, and 83% of the tumors show invasion of adjacent organs or endothoracic metastasis at primary operation. This rate is higher than in cortical thymomas (47%) but lower than in other thymic carcinomas (92%). Two of 18 patients with follow-up died of tumor recurrence and pleural metastasis. Well-differentiated thymic carcinoma can be related to cortical thymoma by common morphological features and a similar immunophenotype of epithelial cells. It must be differentiated from the lymphocyte-depleted cortical thymomas after corticosteroid treatment and from the benign epithelial-rich medullary thymomas.