Small airway inflammation is associated with residual airway hyperresponsiveness in Th2-high asthma
Small airway inflammation is associated with residual airway hyperresponsiveness in Th2-high asthma
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DOI：
10.1080/02770903.2019.1628251
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发表时间：
2019-06-18
影响因子：
1.9
通讯作者：
Niimi, Akio
中科院分区：
文献类型：
--
作者：
Asano, Takamitsu;Kanemitsu, Yoshihiro;Niimi, Akio
背景：哮喘的特点是气道炎症、可变气流阻塞和气道高反应性（AHR）。一般来说，AHR 比气流阻塞或临床症状需要更长的时间才能解决。尽管进行了充分的哮喘治疗，AHR 有时仍会持续存在。目的：评估与看似缓解的气道炎症患者残留 AHR 相关的因素。方法：首次就诊（就诊 1）时表现出高呼出气一氧化氮 (FeNO) 水平 (>25 ppb) 和标准化 FeNO 水平 (
Background: Asthma is characterized by airway inflammation, variable airflow obstruction, and airway hyperresponsiveness (AHR). Generally, AHR takes longer to resolve than does airflow obstruction or clinical symptoms. AHR occasionally persists despite adequate asthma treatment. Objective: To evaluate factors which associates with residual AHR in patients with seemingly remitted airway inflammation. Methods: Patients who exhibited high fractional exhaled nitric oxide (FeNO) levels (>25 ppb) at the first visit (Visit 1) and normalized FeNO levels (