Comparative developmental toxicity of butyltin trichloride, dibutyltin dichloride and tributyltin chloride in rats
Comparative developmental toxicity of butyltin trichloride, dibutyltin dichloride and tributyltin chloride in rats
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三氯化丁基锡、二氯化二丁基锡和氯化三丁基锡对大鼠发育毒性的比较
DOI：
10.1002/jat.2550150411
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发表时间：
1995
影响因子：
3.3
通讯作者：
Y. Ogawa
中科院分区：
文献类型：
--
作者：
M. Ema;R. Kurosaka;H. Amano;Y. Ogawa
比较了丁基锡（BT）、二丁基二氯化锡（DBT）和三丁基氯化锡（TBT）的发育毒性，包括在DBT致畸敏感期给药后的致畸潜力。在怀孕的第7天和第8天，通过胃插管给怀孕的大鼠施用剂量为1000、1500或2000 mg kg−1的BT，剂量为10或15 mg kg−1的DBT或剂量为40或80 mg kg−1的TBT。尽管发生了母体毒性，如1500和2000 mg kg−1组的母体致死率显著增加以及1000和1500 mg kg−1组的母体体重增量降低所证明，但在BT给药后未观察到着床后丢失和畸形胎仔的发生率显著增加。DBT治疗导致母体体重增加显著降低，胎儿体重降低，着床后胚胎死亡率升高。在接受DBT治疗的两个组中，观察到畸形胎仔的发生率显著增加，如露脑畸形、腭裂、唇裂、舌系带过短、马蹄内翻足、颈部和胸部脊柱畸形以及肋骨畸形和肛门或小眼畸形。虽然以40和80毫克/千克的三丁基锡化合物处理导致母体体重增加显著减少，着床后胚胎死亡率增加，但畸形胎儿的发生率没有显著增加。由此可见，BT、DBT和TBT的发育毒性敏感性和发育毒性谱不同。
Butyltin trichloride (BT), dibutyltin dichloride (DBT) and tributyltin chloride (TBT) were compared for their developmental toxicity including teratogenic potential following administration during the susceptible period for the teratogenesis of DBT. Pregnant rats were given either BT at a dose of 1000, 1500 or 2000 mg kg−1, DBT at a dose of 10 or 15 mg kg−1 or TBT at a dose of 40 or 80 mg kg−1 by gastric intubation on days 7 and 8 of pregnancy. Although maternal toxicity occurred, as evidenced by a significantly increased maternal lethality at 1500 and 2000 mg kg−1 and decreased maternal weight gain at 1000 and 1500 mg kg−1, no significant increase in the incidences of postimplantation loss and malformed fetuses were observed after treatment with BT. Treatment with DBT resulted in a significantly lower maternal weight gain, lower fetal weight and higher postimplantation embryolethality. A significantly and markedly increased incidence of fetuses with malformations, such as exencephaly, cleft jaw, cleft lip, ankyloglossia, club foot, deformity of the vertebral column in the cervical and thoracic regions and of the ribs and ano‐ or microphthalmia, was observed in both groups treated with DBT. While treatment with TBT at 40 and 80 mg kg−1 caused a significantly decreased maternal weight gain and increased postimplantation embryolethality, no significantly increased incidence of malformed fetuses occurred. It could be concluded that BT, DBT and TBT are different in the susceptibility and spectrum of developmental toxicity.
母体吸入甲醇后小鼠的阶段特异性发育毒性。
DOI：
10.1006/faat.1993.1127
发表时间：
1993
期刊：
Fundamental and applied toxicology : official journal of the Society of Toxicology
影响因子：
--
作者：
Bolon,B;Dorman,DC;Janszen,D;Morgan,KT;Welsch,F
通讯作者：
Welsch,F