Corticosteroids and thyroid function. Different effects on plasma volume, thyroid hormones and thyroid hormone-binding proteins after oral and intravenous administration.
Corticosteroids and thyroid function. Different effects on plasma volume, thyroid hormones and thyroid hormone-binding proteins after oral and intravenous administration.
复制标题
皮质类固醇和甲状腺功能。
DOI：
10.1111/j.0954-6820.1979.tb06068.x
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发表时间：
2009
影响因子：
--
通讯作者：
B. Söderholm
中科院分区：
文献类型：
--
作者：
A. Gamstedt;G. Järnerot;B. Kågedal;B. Söderholm
研究了17例患者糖皮质激素对血浆容量、甲状腺激素和甲状腺激素结合蛋白的影响。静脉注射β-米松（每日6毫克）或口服泼尼松龙（每日45- 180毫克）5天，对血浆容量没有影响。血清T3浓度下降，而rT 3增加独立的给药途径的皮质类固醇。静脉注射皮质类固醇后血清T4浓度降低，但口服皮质类固醇后没有降低。与静脉注射相比，口服类固醇增加了125 I-三碘甲状腺原氨酸摄取试验值。血清TBG浓度下降独立的给药途径，而血清TBPA浓度增加后，口服皮质类固醇，但静脉注射治疗后不变。血清TSH浓度略有下降。大约一半的患者同时接受皮质类固醇和营养静脉注射，另一半患者接受所有口服治疗。皮质类固醇和热量的给药途径所起的作用，分别，目前无法评估，但这些因素似乎是重要的。
The influence of glucocorticosteroids on plasma volume, thyroid hormones and thyroid hormone-binding proteins was studied in 17 patients. Plasma volume was not affected either by i.v. beta-methasone (6 mg daily) or by oral prednisolone (45--180 mg daily) given for 5 days. The serum T3 concentration decreased while rT3 increased independently of the route of administration of corticosteroids. Serum T4 concentration decreased after i.v. but not after oral administration of corticosteroids. Oral steroids as compared to i.v. increased the 125I-triiodothyronine uptake test value. The serum TBG concentration decreased independently of the route of administration, while the serum TBPA concentration increased after oral corticosteroids but was unchanged after i.v. treatment. The serum TSH concentration was slightly reduced. About half of the patients were given both corticosteroids and nutrition i.v. and the other half were given all treatment by mouth. The part played by the route of administration of corticosteroids and calories, respectively, cannot be evaluated at present but these factors seem to be of importance.