Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome
Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome
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DOI：
10.1136/gut.39.5.741
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发表时间：
1996-11-01
期刊：
影响因子：
24.5
通讯作者：
Frexinos, J
中科院分区：
文献类型：
--
作者：
Louvel, D;Delvaux, M;Frexinos, J
目的：在26名肠易激综合征（IBS）患者中，使用一个放置在降结肠并连接到计算机化恒压器的松弛袋，评估催产素对结肠感觉管腔内扩张的影响。（第一感觉和疼痛）进行了评估，在等压扩张（4 mm Hg增量，5分钟持续时间，5分钟间隔，每个步骤之间返回到零压力），由恒压器自动执行，在连续输注安慰剂或不同剂量的催产素（10、20、30和50 mU/min）期间。3（5 . 5)mmHg，安慰剂组，19 . 9（5 . 8)催产素10 mU/min（NS）组22 . 3（6 . 0)毫米汞柱催产素20 mU/min（p
Aim-The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.Method-Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various doses of oxytocin (10, 20, 30, and 50 mU/min).Results-The distension pressure (mean (SD)) required to induce a first abdominal sensation was 17 . 3 (5 . 5) mm Hg on placebo, 19 . 9 (5 . 8) on oxytocin 10 mU/min (NS), 22 . 3 (6 . 0) mm Hg on oxytocin 20 mU/min (p