Determination of Serum Unbound Bilirubin for Prediction of Kernicterus in Low Birthweight infants
Determination of Serum Unbound Bilirubin for Prediction of Kernicterus in Low Birthweight infants
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测定血清游离胆红素以预测低出生体重婴儿的核黄疸
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
Yokei Lee
中科院分区：
文献类型：
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作者：
Hajime Nakamura;M. Yonetani;Y. Uetani;Masafumi Funato;Yokei Lee
对138例低出生体重儿（LBW）接受光疗治疗的非溶血性高胆红素血症患者的血清未结合胆红素浓度（UBC）和血清总胆红素浓度（TBC）进行了连续测定。我们试图将预测胆红素脑病的临界UBC水平分为两个不同的出生体重组：极低出生体重（VLBW）组（出生体重< 1,500 g）和LBW组（出生体重在1,500 g和2,499 g之间）。12名婴儿被诊断为核黄疸的“危险”，其中11人有急性胆红素脑病和换血的迹象。一名VLBW婴儿在3年随访中出现神经系统后遗症，尽管由于TBC低而未进行换血。
Serum unbound bilirubin concentrations (UBC) and serum total bilirubin concentrations (TBC) were measured serially in 138 low birthweight (LBW) infants treated with phototherapy for non‐hemolytic hyperbilirubinemia. We attempted to assign the suitable critical UBC levels for predicting bilirubin encephalopathy into two different birthweight groups: a very low birthweight (VLBW) group (birthweight < 1,500 g) and an LBW group (birthweight between 1,500 g and 2,499 g). Twelve infants were diagnosed as ‘at risk’ for kernicterus, of whom 11 had signs of acute bilirubin encephalopathy and exchange transfusion. One VLBW infant had neurological sequelae at a 3 year follow‐up, although exchange transfusion was not carried out because of low TBC.