Binge cocaine self-administration in humans: intravenous cocaine.
Binge cocaine self-administration in humans: intravenous cocaine.
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人类狂饮可卡因自我给药：静脉注射可卡因。
DOI：
10.1007/s002130050358
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发表时间：
1997
影响因子：
3.4
通讯作者：
Foltin,RW
中科院分区：
文献类型：
--
作者：
Ward,AS;Haney,M;Fischman,MW;Foltin,RW
可卡因经常用于重复给药的间歇性周期，或“狂欢”。这种可卡因使用模式很难在人类中进行研究，因为目前可用的实验室模型仅使用每日一次的单剂量或多剂量给药。在本研究中，7名成年男性静脉注射可卡因使用者完成了一项研究方案，调查在重复自我管理可卡因的心血管和主观反应的变化。志愿者参与了2天和3天的访问条件。在访问的每一天，他们参加了两个2.5小时的会议，一个在12时，另一个在16时。 在2天和3天的条件下，参与者分别连续2天或3天获得可卡因。在会议期间，参与者可以每14分钟自我注射多达6剂可卡因（32 mg/70 kg）。 在420次试验中，只有10%的参与者选择不自己服用可卡因。 对可卡因的心血管和几种主观效应产生了急性耐受性。心率是唯一的措施，往往会减少跨天重复可卡因自我管理。在2天和3天的条件下，在最后一次自我给药结束时，“我要可卡因”的评分下降。对于任何测量，2天和3天条件之间没有差异。本研究建立的“狂欢”可卡因使用的实验室模型可用于描述重复使用可卡因的发作内和发作之间可卡因的心血管和主观效应的变化。
Cocaine is frequently used in intermittent cycles of repeated dosing, or “binges.” This pattern of cocaine use has been difficult to study in humans because currently available laboratory models use only one daily session during which a single dose or multiple doses are administered. In the present study, seven adult male IV cocaine users completed a protocol investigating changes in cardiovascular and subjective responses during the repeated self-administration of cocaine. Volunteers participated in a 2-day and a 3-day access condition. On each day of access, they participated in two 2.5-h sessions, one at 1200 and another at 1600 hours. In the 2- and 3-day conditions, participants had access to cocaine on 2 or 3 consecutive days, respectively. During sessions, participants could self-administer up to six doses of IV cocaine (32 mg/70 kg) every 14 min. Participants chose not to self-administer cocaine on only 10% of the 420 trials. Acute tolerance developed to the cardiovascular and several subjective effects of cocaine. Heart rate was the only measure that tended to decrease across days of repeated cocaine self-administration. Ratings of “I want cocaine” decreased at the end of the last self-administration session during both 2- and 3-day conditions. There was no difference between the 2- and 3-day conditions for any measure. The laboratory model of “binge” cocaine use established in this study can be used to describe changes in cardiovascular and subjective effects of cocaine within and between bouts of repeated cocaine use.