Hydrolytically degradable shells on thermoresponsive microgels
Hydrolytically degradable shells on thermoresponsive microgels
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DOI：
10.1007/s00396-012-2692-0
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发表时间：
2013-01-01
影响因子：
2.4
通讯作者：
Lyon, L. Andrew
中科院分区：
文献类型：
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作者：
Gaulding, Jeffrey C.;South, Antoinette B.;Lyon, L. Andrew
以可降解交联剂N，O-二甲基丙烯酰羟胺为交联剂，合成了以聚N-异丙基丙烯酰胺为核、聚N-异丙基甲基丙烯酰胺为壳的温敏微凝胶。利用动态光散射、非对称流场-流动分离-多角度光散射和原子力显微镜等多种分析工具对其溶胀和侵蚀性能进行了表征。由于所添加的聚合物和壳体所施加的机械压力，壳体的加入会导致颗粒致密。壳层交联物的水解性降解后，整个核壳和壳层都会发生机械和化学变化，导致壳更软、更多孔，从而允许更大的岩心膨胀。这些变化是在暴露于生理条件下触发的，在触发药物输送领域具有潜在的用途。
Thermoresponsive microgels consisting of poly(N-isopropylacrylamide) cores and poly(N-isopropylmethacrylamide) shells cross-linked with the hydrolytically degradable cross-linker N,O-dimethacryloyl hydroxylamine were synthesized. Their swelling and erosion properties were characterized using a variety of analytical tools including dynamic light scattering, asymmetrical flow field-flow fractionation-multiangle light scattering, and atomic force microscopy. Shell addition leads to particle densification due to the added polymer and the mechanical, compressive force applied by the shell. Upon hydrolytic degradation of the shell cross-links, mechanical and chemical changes occur throughout the core and shell, leading to softer and more porous shells that permit greater core swelling. Such changes, which are triggered on exposure to physiologic conditions, are of potential utility within the realm of triggered drug delivery.