The comparison of early healing 1-month after PCI among CoCr-everolimus-eluting stent (EES), biodegradable polymer (BP)-EES and BP-sirolimus-eluting stent: Insights from OFDI and coronary angioscopy.
The comparison of early healing 1-month after PCI among CoCr-everolimus-eluting stent (EES), biodegradable polymer (BP)-EES and BP-sirolimus-eluting stent: Insights from OFDI and coronary angioscopy.
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DOI：
10.1016/j.ijcha.2018.08.001
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发表时间：
2018-09
期刊：
影响因子：
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通讯作者：
Aizawa Y
中科院分区：
文献类型：
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作者：
Sato T;Taya Y;Suzuki N;Yuasa S;Kishi S;Koshikawa T;Fuse K;Fujita S;Ikeda Y;Kitazawa H;Takahashi M;Okabe M;Aizawa Y
采用腔内生物可降解聚合物（BP）的第三代支架可能有助于早期愈合。因此，我们使用冠状动脉血管镜（CAS）和光学频域成像（OFDI）比较了第二代和第三代支架的早期愈合情况。我们前瞻性地连续招募30例急性冠脉综合征支架植入术患者（钴铬[CoCr]依维莫司洗脱支架[EES] [n = 10],BP-EES [n = 10]，bp -西罗莫司洗脱支架[SES] [n = 10]）。所有患者在首次经皮冠状动脉介入治疗后1 个月接受了CAS和OFDI。在OFDI中，评估支架覆盖（SC）、血栓和支架周围低强度区域（PLIA）。记录CAS结果的SC分级、黄色分级（YC）和血栓分级（TG）。在OFDI中，CoCr-EES组、BP-EES组和BP-SES组在1个月随访时血栓的发生率分别为70%、80%和80%。两组间的覆盖率具有可比性（CoCr-EES 79.8 vs BP-EES 79.9 vs BP-SES 80.1%, P = 0.96）。然而，BP-SES组PLIA的支杆数量高于CoCr-EES组和BP-EES组（46.4 ± 25.1 vs. 21.6 ± 13.2 vs. 22.0 ± 7.2%,P = 0.08）。CoCr-EES组、BP-EES组和BP-SES组SC的平均分级分别为1.25 ± 0.5、1.25 ± 0.5和0.85 ± 0.70 (P = 0.60)；平均成绩YC的0.75 ± 0.5,0.80 ± 0.45,和0.88 ± 0.37 (P = 0.65),TG和平均成绩分别为1.00 ± 1.00,1.20 ± 0.83,和0.88 ± 0.64 (P = 0.75),分别。在支架覆盖方面，第三代支架并不亚于第二代支架。然而，BP-SESs经常观察到OFDI上的PLIA，表明纤维蛋白成分的参与。
Third-generation stents with abluminal biodegradable polymer (BP) might facilitate early healing. Therefore, we compared early healing between second-generation and third-generation stents using coronary angioscopy (CAS) and optical frequency domain imaging [OFDI]. We prospectively enrolled 30 consecutive patients with stent implantation for acute coronary syndrome (cobalt‑chromium [CoCr] everolimus-eluting stent [EES] [n = 10], BP-EES [n = 10], and BP-sirolimus eluting stent [SES] [n = 10]). All patients underwent CAS and OFDI 1 month after initial percutaneous coronary intervention. On OFDI, the stent coverage (SC), thrombus, and peri-strut low intensity area (PLIA) were assessed. CAS findings were recorded for the grade of SC, grade of yellow color (YC), and grade of the thrombus (TG). On OFDI, the incidences of any thrombus at the 1-month follow-up were 70%, 80%, and 80% in the CoCr-EES, BP-EES, and BP-SES groups, respectively. The percentage of coverage was comparable among the groups (CoCr-EES 79.8 vs. BP-EES 79.9 vs. BP-SES 80.1%, P = 0.96). However, the number of struts with PLIA was numerically higher in the BP-SES group than in the CoCr-EES and BP-EES groups (46.4 ± 25.1 vs. 21.6 ± 13.2 vs. 22.0 ± 7.2%, P = 0.08). In the CoCr-EES, BP-EES, and BP-SES groups, mean grades of SC were 1.25 ± 0.5, 1.25 ± 0.5, and 0.85 ± 0.70 (P = 0.60); mean grades of YC were 0.75 ± 0.5, 0.80 ± 0.45, and 0.88 ± 0.37 (P = 0.65), and mean grades of TG were 1.00 ± 1.00, 1.20 ± 0.83, and 0.88 ± 0.64 (P = 0.75), respectively. Third-generation stents are not inferior to second-generation stents regarding stent coverage. However, PLIA on OFDI was often observed with BP-SESs, indicating involvement of the fibrin component.