Factors controlling measures of anxiety and responses to novelty in the mouse
Factors controlling measures of anxiety and responses to novelty in the mouse
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DOI：
10.1016/s0166-4328(01)00292-3
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发表时间：
2001-11-01
影响因子：
2.7
通讯作者：
File, SE
中科院分区：
文献类型：
--
作者：
File, SE
本文综述了高架十字迷宫、洞板和食物偏好的社会传播中影响行为的因素。高架十字迷宫提供了独立的焦虑（在开放臂上花费的时间百分比）和活动（闭合臂条目数）的测量方法，可用于男性和女性。重要的性别差异出现在因素负荷，而在男性中，焦虑是主要因素，在女性中，它是活动。在十字迷宫的第二次试验中，焦虑状态的性质改变，因此该迷宫可用于筛选两种不同焦虑状态中可能的遗传改变。洞板提供了探索和运动活动的独立测量，并且会话之间的习惯化提供了有用的学习测量。老鼠表现出新恐惧症，避免新的食物。但关于他们安全的信息可以通过社会传播。一只尝过新食物的老鼠在回到殖民地时会被其他老鼠积极地嗅闻。重要的是要控制可能的变化，在社会调查，新恐惧症。嗅觉灵敏度焦虑和探索，然后得出结论，在这项任务中的变化表现是由于学习的变化。(C)2001 Elsevier Science B.V.保留所有权利。
This review focuses on factors influencing behaviour in the elevated plus-maze, the holeboard and the social transmission of food preference, The elevated plus-maze provides independent measures of anxiety (percentage of time spent on open arms) and activity (number of closed arm entries) and can be used in both males and females. Important sex differences emerge in factor loadings, and, whereas in males, anxiety is the primary factor, in females it is activity. On trial 2 in the plus-maze., the nature of the anxiety state is changed and thus this maze can be used to screen for possible genetic alterations in two distinct anxiety states. The holeboard provides independent measures of exploration and locomotor activity and habituation between sessions provides a useful measure of learning. Mice display neophobia and avoid novel foods. but information about their safety can be socially transmitted. A mouse that has sampled a novel food will be actively sniffed by others on its return to the colony. It is important to control for possible changes in social investigation, neophobia. olfactory sensitivity. anxiety and exploration, before it is concluded that a changed performance in this task is due to changes in learning. (C) 2001 Elsevier Science B.V. All rights reserved.