Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.
Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.
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DOI：
10.1073/pnas.79.24.7809
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发表时间：
1982-12
影响因子：
11.1
通讯作者：
J. Trent;S. Olson;R. Lawn
中科院分区：
文献类型：
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作者：
J. Trent;S. Olson;R. Lawn
将含有人白细胞干扰素（IFN-α）、成纤维细胞干扰素（IFN-β）或免疫干扰素（INF-γ）基因cDNA插入片段的重组质粒进行放射性标记，并与人中期染色体制备物原位杂交。结果将人IFN-α和IFN-β基因定位于9号染色体的短臂（p21-->pter），并将IFN-γ基因定位于12号染色体的长臂（q24.1）。
Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-alpha), fibroblast interferon (IFN-beta), or immune interferon (INF-gamma) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-alpha and IFN-beta genes to the short arm of chromosome 9(p21-->pter) and localized the IFN-gamma gene to the long arm of chromosome 12(q24.1).