Diagnostic, Prognostic, and Therapeutic Value of Circulating miRNAs in Heart Failure Patients Associated with Oxidative Stress.
Diagnostic, Prognostic, and Therapeutic Value of Circulating miRNAs in Heart Failure Patients Associated with Oxidative Stress.
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循环 miRNA 在与氧化应激相关的心力衰竭患者中的诊断、预后和治疗价值
DOI：
10.1155/2016/5893064
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发表时间：
2016
影响因子：
--
通讯作者：
Ping Z
中科院分区：
文献类型：
--
作者：
Ali Sheikh MS;Salma U;Zhang B;Chen J;Zhuang J;Ping Z
心力衰竭是一个主要的公共卫生问题，尤其是在老龄化人群（≥65岁）中，影响近500万美国人和1500万欧洲人。心力衰竭（HF）的有效管理取决于正确和快速的诊断。目前，BNP（脑利钠肽）或N-末端脑利钠肽前体（NT-proBNP）测定被国际社会普遍接受用于HF患者的诊断评估和风险分层。然而，尽管其广泛的临床应用，BNP仍然受到特异性降低的阻碍。因此，心力衰竭的诊断仍然具有挑战性。尽管在过去的20年中，HF的临床管理发生了显著的改善，但传统治疗在许多进展为晚期HF的患者中最终无效。因此，HF患者的临床管理需要新的诊断、预后生物标志物和新的治疗方法。循环miRNA似乎是新型非侵入性生物标志物以及HF新治疗策略的正确选择。在这篇综述中，我们简要讨论了循环中的miRNAs在心力衰竭患者的诊断，预后和治疗作用。我们还提到了我们自己的RNA提取技术和从人血浆中检测循环miRNA以及与HF相关的氧化应激miRNA。
Heart failure is a major public health problem especially in the aging population (≥65 years old), affecting nearly 5 million Americans and 15 million European people. Effective management of heart failure (HF) depends on a correct and rapid diagnosis. Presently, BNP (brain natriuretic peptide) or N-terminal pro-brain natriuretic peptide (NT-proBNP) assay is generally accepted by the international community for diagnostic evaluation and risk stratification of patients with HF. However, regardless of its widespread clinical use, BNP is still encumbered by reduced specificity. As a result, diagnosis of heart failure remains challenging. Although significant improvement happened in the clinical management of HF over the last 2 decades, traditional treatments are ultimately ineffective in many patients who progress to advanced HF. Therefore, a novel diagnostic, prognostic biomarker and new therapeutic approach are required for clinical management of HF patients. Circulating miRNAs seem to be the right choice for novel noninvasive biomarkers as well as new treatment strategies for HF. In this review, we briefly discuss the diagnostic, prognostic, and therapeutic role of circulating miRNAs in heart failure patients. We also mentioned our own technique of extraction of RNA and detection of circulating miRNAs from human plasma and oxidative stress associated miRNAs with HF.