Cholangiofibrosis induced by short-term feeding of 3'-methyl-4-(dimethylamino)azobenzene: an electron microscopic observation.
Cholangiofibrosis induced by short-term feeding of 3'-methyl-4-(dimethylamino)azobenzene: an electron microscopic observation.
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短期喂养 3-甲基-4-(二甲氨基)偶氮苯诱导的胆管纤维化：电子显微镜观察。
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
Masayuki Nakano
中科院分区：
文献类型：
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作者：
Kiyoshi Terao;Masayuki Nakano
本文观察了短期喂饲3 ′-甲基-4-二甲氨基偶氮苯（3 ′-Me-DAB）诱导的大鼠肝胆管纤维化的超微结构。喂食3 '-Me-DAB短至2周的时间足以诱导胆管纤维化。停止喂食致癌物后，胆管纤维化病变继续生长长达25周。从停止染料喂养后8周开始观察到病变的玻璃样变。但在玻璃样变的病变周边区，常可见到新生的衬里上皮细胞。胆管纤维化病变上皮衬里细胞的超微结构表现为典型的肠上皮细胞化生，包括杯状细胞、肠嗜铬细胞和潘氏细胞。经常观察到纹状边缘的精细结构的变化。
The ultrastructure of cholangiofibrosis in a rat liver induced by short-term feeding with 3'-methyl-4-(dimethylamino)azobenzene (3'-Me-DAB) was investigated. The feeding of 3'-Me-DAB for as short a period as 2 weeks was sufficient to induce cholangiofibrosis. After cessation of the feeding of the carcinogen, lesions of cholangiofibrosis continued to grow for up to 25 weeks. Hyalinization of the lesions was seen from 8 weeks after stopping of the dye feeding. However, the newly proliferated lining epithelial cells at the peripheral zone of the hyalinized lesions could always be seen. The ultrastructure of the epithelial lining cells in the lesion of cholangiofibrosis showed a typical intestinal cell metaplasia including goblet cells, enterochromaffin cells, and Paneth cells. A variation in the fine structure of the striated border was often observed.