Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris
Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris
复制标题
成纤维细胞生长因子 21 的循环水平与不稳定心绞痛的风险独立相关
DOI：
10.1042/bsr20181099
复制
发表时间：
2018-10-31
影响因子：
4
通讯作者：
Chen, Wenqiang
中科院分区：
文献类型：
--
作者：
Cheng, Jing;Su, Xing;Chen, Wenqiang
越来越多的证据表明，血清脂肪因子水平与心血管疾病的高风险有关。成纤维细胞生长因子21（fibroblast growth factor 21，FGF 21）是一种重要的脂肪细胞因子，与动脉粥样硬化和冠状动脉疾病（coronary artery disease，CAD）密切相关。然而，心绞痛患者的循环FGF 21水平尚未研究。检测了197例稳定型心绞痛（SAP，n=66）、不稳定型心绞痛（UAP，n=76）和对照组（n=55）患者的循环FGF 21水平，并与心血管危险因素的临床变量一起进行沿着。入院时血清FGF 21浓度在UAP组显著高于SAP组（Ln-FGF 21：5.26 ± 0.87 vs 4.85 ± 0.77，P < 0.05）和对照组（自然对数（Ln）-FGF 21：5.26 ± 0.87 vs 4.54 ± 0.72，P < 0.01）。相关分析显示，血清FGF 21浓度与心肌肌钙蛋白I（cTnI）（r（2）= 0.026，P=0.027）和肌酸激酶MB（CK-MB）（r（2）= 0.023，P=0.04）呈正相关。此外，在调整性别、年龄和体重指数（BMI）后，FGF 21水平被确定为与UAP风险相关的独立因素（比值比（OR）：2.781; 95%CI：1.476-5.239; P=0.002）。而血清FGF 21水平与SAP的发生无相关性（OR：1.248; 95% CI：0.703-2.215; P=0.448）。本研究表明，FGF 21与不稳定型心绞痛的风险增加有很强的相关性和精确的预测性，独立于传统的心绞痛危险因素。
There is increasing evidence that serum adipokine levels are associated with higher risks of cardiovascular diseases. As an important adipokine, fibroblast growth factor 21 (FGF21) has been demonstrated to be associated with atherosclerosis and coronary artery disease (CAD). However, circulating level of FGF21 in patients with angina pectoris has not yet been investigated. Circulating FGF21 level was examined in 197 patients with stable angina pectoris (SAP, n=66), unstable angina pectoris (UAP, n=76), and control subjects (n=55) along with clinical variables of cardiovascular risk factors. Serum FGF21 concentrations on admission were significantly increased more in patients with UAP than those with SAP (Ln-FGF21: 5.26 +-0.87 compared with 4.85 +/- 0.77, P < 0.05) and control subjects (natural logarithm (Ln)-FGF21: 5.26 +/- 0.87 compared with 4.54 +/- 0.72, P < 0.01). The correlation analysis revealed that serum FGF21 concentration was positively correlated with the levels of cardiac troponin I (cTnI) (r(2) = 0.026, P=0.027) and creatine kinase-MB (CK-MB) (r(2) = 0.023, P=0.04). Furthermore, FGF21 level was identified as an independent factor associated with the risks of UAP (odds ratio (OR): 2.781; 95% CI: 1.476-5.239; P=0.002), after adjusting for gender, age, and body mass index (BMI). However, there were no correlations between serum FGF21 levels and the presence of SAP (OR: 1.248; 95% CI: 0.703-2.215; P=0.448). The present study indicates that FGF21 has a strong correlation and precise predictability for increased risks of UAP, that is independent of traditional risk factors of angina pectoris.