Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain.
Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain.
复制标题
DOI：
10.1016/j.expneurol.2008.12.020
复制
发表时间：
2009-04
影响因子：
5.3
通讯作者：
Sharp, Frank R.
中科院分区：
文献类型：
--
作者：
Lu, Aigang;Clark, Joseph F.;Broderick, Joseph P.;Pyne-Geithman, Gail J.;Wagner, Kenneth R.;Khatri, Pooja;Tomsick, Thomas;Sharp, Frank R.
急性脑动脉闭塞后再通治疗的主要并发症是出血性转化（HT）。虽然已经知道长时间的缺血在HT的发展中是重要的，但是再灌注在缺血再灌注诱导的HT中的作用还没有得到很好的研究。为了解决再灌注对HT的影响，我们评估了大脑中动脉闭塞（MCAO）5小时后再灌注19小时的大鼠出血的发生率和严重程度，并与永久闭塞（PMCAO）大鼠在相同的24小时时间点进行比较。测量出血发生率和出血量、神经功能和死亡率。与PMCAO相比，MCAO（5 h）再灌注19 h与皮质出血的发生率显著较高（81.8% vs 18.2%，p < 0.05）。与PMCAO大鼠相比，5小时MCAO/再灌注组的出血评分更高（皮质17.6 ± 11.5 vs 2.4 ± 5.3，纹状体20.4 ± 4.6 vs 9.7 ± 4.5，p<0.01）。与PMCAO组相比，缺血-再灌注组的神经功能更差（p < 0.05），而5小时MCAO/再灌注组的死亡率与PMCAO组相比无显著性差异（54.5% vs18.1%; p < 0.08）。结果表明，与永久性缺血相比，长时间缺血后再灌注与出血性转化和神经功能恶化增加有关。再灌注前的药物治疗是否能减轻缺血后HT需要进一步研究。
A major complication of recanalization therapy after an acute arterial occlusion in brain is hemorrhagic transformation (HT). Although it is known that prolonged ischemia is important in the development of HT, the role of reperfusion in ischemia reperfusion induced HT is less well studied. To address the effect of reperfusion on HT, we assessed the incidence and severity of hemorrhage in rats after five hours of middle cerebral artery occlusion (MCAO) followed by 19h reperfusion compared to rats with permanent occlusion (PMCAO) at the same 24h time point. The incidence and amount of hemorrhage, neurological function, and mortality rates were measured. MCAO (5h) with 19h reperfusion was associated with a significantly higher incidence of cortical hemorrhage compared to PMCAO (81.8% vs 18.2%, p < 0.05). Hemorrhage scores were higher in the 5-hour MCAO/reperfusion group compared to PMCAO rats (17.6 ± 11.5 vs 2.4 ± 5.3 in cortex, 20.4 ± 4.6 vs 9.7 ± 4.5 in striatum, p<0.01). Neurological function was worse in the ischemia-reperfusion group compared to PMCAO (p < 0.05) and mortality rates were insignificantly higher in the five-hour MCAO/reperfusion group vs PMCAO group (54.5 % vs18.1%; p < 0.08). The results suggest that reperfusion after prolonged ischemia is associated with increased hemorrhagic transformation and neurological deterioration as compared to permanent ischemia. Whether pharmacological treatments prior to reperfusion attenuate post-ischemic HT requires further study.
登录
查看更多内容
影响因子：
1.9
作者：
Fagan, SC;Nagaraja, TN;Knight, RA
通讯作者：
Knight, RA
影响因子：
9.9
作者：
MORI, E;YONEDA, Y;YAMADORI, A
通讯作者：
YAMADORI, A
影响因子：
2.9
作者：
Lin, BW;Ginsberg, MD
通讯作者：
Ginsberg, MD
影响因子：
8.3
作者：
Morita-Fujimura, Y;Fujimura, M;Chan, PH
通讯作者：
Chan, PH
影响因子：
8.3
作者：
Choudhri, TF;Hoh, BL;Pinsky, DJ
通讯作者：
Pinsky, DJ