Clinical and laboratory aspects of dyslipidemia in Brazilian women with systemic lupus erythematosus
Clinical and laboratory aspects of dyslipidemia in Brazilian women with systemic lupus erythematosus
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DOI：
10.1007/s10067-018-4051-0
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发表时间：
2018-06-01
影响因子：
3.4
通讯作者：
Sousa Atta, Maria Luiza B.
中科院分区：
文献类型：
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作者：
Atta, Ajax M.;Silva, Joao Paulo C. G.;Sousa Atta, Maria Luiza B.
系统性红斑狼疮（SLE）与血脂异常、动脉粥样硬化和心血管疾病有关。在这项研究中，我们通过评估巴西SLE患者的血脂谱和免疫状态，包括动脉粥样硬化形成中自身抗体和细胞因子的产生，调查了他们是否存在血脂异常。94名女性SLE患者参加了这项研究，根据他们的血脂谱，被归类为血脂异常或没有。所有人都进行了抗核抗体（ANA），抗磷脂抗体，可提取的核抗原和双链DNA的自身抗体。测定载脂蛋白A和B、C3、C4和C反应蛋白的血清水平，以及白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和IL-10的血清水平。根据系统性红斑狼疮疾病活动指数2000对狼疮活动性进行评分。69例患者（73.4%）有血脂异常，其余25例患者（26.6%）为非血脂异常。狼疮活动与非高密度脂蛋白胆固醇和甘油三酯（TG）水平相关（非HDL-C，分别为r = 0.34和p = 0.0043和r = 0.46和p < 0.0001）。血脂异常妇女的动脉粥样硬化指数载脂蛋白B/载脂蛋白A和TG：HDL-C比值较高，TG：HDL与疾病活动性相关（r = 0.40，p = 0.0007）。IL-6、TNF-α和IL-10水平在组间相似;然而，仅在血脂异常组中观察到IL-6和CRP水平之间的正相关性（r = 0.55，p < 0.0001）。巴西女性SLE患者血脂异常患病率高，与无血脂异常的女性SLE患者和健康个体相比，表现出更高的心血管疾病风险。
Systemic lupus erythematosus (SLE) is associated with dyslipidemia, atherosclerosis, and cardiovascular disease. In this study, we investigated the presence of dyslipidemia in Brazilian SLE patients by evaluating their lipid profile and immune status, including the production of autoantibodies and cytokines involved in atherogenesis. Ninety-four female SLE patients participated in this study and, based on their lipid profile, were classified as dyslipidemic or not. All were tested for antinuclear antibodies (ANAs), antiphospholipid antibodies, and autoantibodies to extractable nuclear antigens and double-stranded DNA. Serum levels of apolipoproteins A and B, C3, C4, and C-reactive protein were measured, as well as serum levels of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and IL-10. Lupus activity was scored according to the Systemic Lupus Erythematosus Disease Activity Index 2000. Sixty-nine patients (73.4%) had dyslipidemia, and the remaining 25 patients (26.6%) were non-dyslipidemic. Lupus activity was correlated with non-high-density lipoprotein cholesterol and triglyceride (TG) levels (non-HDL-C, r = 0.34 and p = 0.0043 and r = 0.46 and p < 0.0001, respectively). Atherogenic indexes apolipoprotein B/apolipoprotein A and TG:HDL-C ratios were higher in dyslipidemic women, and TG:HDL was correlated with disease activity (r = 0.40, p = 0.0007). IL-6, TNF-alpha, and IL-10 levels were similar between groups; however, a positive correlation between IL-6 and CRP levels was only observed in the group with dyslipidemia (r = 0.55, p < 0.0001). Female Brazilian SLE patients present a high prevalence of dyslipidemia and exhibit a higher risk of cardiovascular diseases as compared with female SLE patients without dyslipidemia and healthy individuals.