Neuromuscular Specializations of the Human Hypopharyngeal Muscles.
Neuromuscular Specializations of the Human Hypopharyngeal Muscles.
复制标题
人类下咽肌的神经肌肉专门化。
DOI：
10.1007/s00455-020-10212-0
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发表时间：
2021
期刊：
影响因子：
2.6
通讯作者：
Abdelfattah,HeshamMostafa
中科院分区：
文献类型：
--
作者：
Mohammed,MohammedElrabieAhmed;Mu,Liancai;Abdelfattah,HeshamMostafa
人类的下咽肌在吞咽、说话和呼吸中起着至关重要的作用。越来越多的证据表明，这些肌肉专门执行维持生命的上呼吸消化功能。本文综述了下咽肌的主要结构、生理和生化特征，包括神经支配、收缩特性、组织化学、生化特性、肌球蛋白重链（MyHC）的表达和调控以及年龄相关的改变。这些将阐明人类下咽肌的独特神经肌肉特化，以更好地理解咽的功能和病理状况，并开发治疗相关上呼吸道疾病的新疗法。
The hypopharyngeal muscles in humans play a vital role in swallowing, speech, and respiration. Increasing evidence indicates that these muscles are specialized to perform life-sustaining upper aerodigestive functions. This review aims to provide current knowledge regarding the key structural, physiological, and biochemical features of the hypopharyngeal muscles, including innervation, contractile properties, histochemistry, biochemical properties, myosin heavy chain (MyHC) expression and regulation, and age-related alterations. These would clarify the unique neuromuscular specializations of the human hypopharyngeal muscles for a better understanding of the functions and pathological conditions of the pharynx and for the development of novel therapies to treat related upper airway disorders.