Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion.
Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion.
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反复接触可卡因会导致催乳素和肾素的血清素刺激产生长期缺陷，但不会影响促肾上腺皮质激素的分泌。
DOI：
10.1016/0014-2999(93)90215-4
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发表时间：
1993
影响因子：
5
通讯作者：
VandeKar,LD
中科院分区：
文献类型：
--
作者：
Levy,AD;Rittenhouse,PA;Bonadonna,AM;AlvarezSanz,MC;Bethea,CL;VandeKar,LD
为了确定可卡因诱导的多巴胺能功能缺陷是否是持久的，在可卡因暴露7天（15 mg/kg b.i.d.）后1-8周评价了对5-羟色胺（5-羟色胺，5-HT）受体、对氯苯丙胺的神经内分泌反应。在可卡因预处理的大鼠中，对氯苯丙胺诱导的催乳素和肾素分泌升高分别显著降低8周和4周。与此相反，可卡因暴露后1周，p-氯苯丙胺诱导的促肾上腺皮质激素（ACTH）分泌升高处于对照值。这些数据表明，一些可卡因诱导的多巴胺能功能的缺陷是持久的。
To determine whether cocaine-induced deficits in serotonergic function are long-lasting, the neuroendocrine responses to the serotonin (5-hydroxytryptamine, 5-HT) releaser, p-chloroamphetamine were evaluated 1–8 weeks subsequent to 7 days of cocaine exposure (15 mg/kg b.i.d.). In cocaine-pretreated rats, the p-chloroamphetamine-induced elevations of prolactin and renin secretion were significantly reduced for 8 and 4 weeks, respectively. In contrast, the p-chloroamphetamine-induced elevation of adrenocorticotropic hormone (ACTH) secretion was at control values 1 week after cocaine exposure. The data suggest that some cocaine-induced deficits in serotonergic function are long-lasting.