Cross-Sectional Study Examining the Association Between Metabolic Syndrome and Cognitive Function Among the Oldest Old
Cross-Sectional Study Examining the Association Between Metabolic Syndrome and Cognitive Function Among the Oldest Old
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DOI：
10.1016/j.jamda.2012.10.001
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发表时间：
2013-02-01
影响因子：
7.6
通讯作者：
Dong, Birong
中科院分区：
文献类型：
--
作者：
Luo, Li;Yang, Ming;Dong, Birong
目的：代谢综合征（MetS），包括肥胖、高血压、血脂异常和胰岛素抵抗，已被证明易使人患认知障碍和痴呆。在这项研究中，我们的目的是研究代谢综合征和认知功能障碍之间的关系，最古老的老人使用一个队列的中国个人年龄在90至108 years.Methods：长寿和老龄化的项目在都江堰是一个以人口为基础的研究870人年龄在90岁及以上。认知功能进行了评估，使用简易精神状态检查，静脉血样本后，收集一夜之间快速测量生化indicators.Results：在767参与者进行这项分析，平均年龄为93.6 +/- 3.3岁（范围90-108岁），516（67.3%）是女性，53百岁老人。平均简易精神状态检查评分为15.0 +/- 5.9。代谢综合征总患病率为9.3%。在调整了年龄、性别、教育水平、吸烟、饮酒和锻炼等因素后，总人群中，代谢综合征与认知障碍的比值比（OR）较低（OR 0.443，95%CI，0.255-0.769）相关。在男性中，高甘油三酯水平与认知功能损害的OR值较低相关（OR = 0.434，95%CI，0.191-0.989）。在男性九旬老人和百岁老人中，高甘油三酯水平和收缩压，这是代谢综合征的一部分，也与更好的认知功能有关。版权所有（C）2013 -美国医学主任协会，Inc.
Objectives: Metabolic syndrome (MetS), which includes obesity, hypertension, dyslipidemia, and insulin resistance, has been shown to predispose people to cognitive impairment and dementia. In this study, we aimed to examine the relationship between MetS and cognitive impairment among the oldest-old people using a cohort of Chinese individuals aged 90 to 108 years.Methods: The Project of Longevity and Aging in Dujiangyan is a population-based study of 870 people aged 90 years and older. Cognitive function was evaluated using Mini-Mental State Examination, and venous blood samples were collected after an overnight fast to measure the biochemistry indicators.Results: Among the 767 participants for this analysis, the mean age was 93.6 +/- 3.3 years (range 90-108 years), 516 (67.3%) were women, and 53 were centenarians. The mean Mini-Mental State Examination score was 15.0 +/- 5.9. The total prevalence rate of MetS was 9.3%. After adjusting for age, sex, educational levels, smoking, drinking, and exercise, MetS was associated with a lower odds ratio (OR) of having cognitive impairment (OR 0.443, 95% CI, 0.255-0.769) among the total population. Among men, a high triglyceride level was also associated with a lower OR of having cognitive impairment (OR 0.434, 95% CI, 0.191-0.989).Conclusion: MetS may be associated with better cognitive function among the oldest old. Among male nonagenarians and centenarians, high triglyceride level and systolic blood pressure, which are parts of MetS, are also associated with better cognitive function. Copyright (C) 2013 - American Medical Directors Association, Inc.