Hepatitis C virus infection in inclusion body myositis A case-control study

Hepatitis C virus infection in inclusion body myositis A case-control study
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DOI：
10.1212/wnl.0000000000002291
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发表时间：
2016-01-19
期刊：
NEUROLOGY
影响因子：
9.9
通讯作者：
Nishino, Ichizo
Nishino, Ichizo
中科院分区：
医学1区
文献类型：
--
作者：
Uruha, Akinori;Noguchi, Satoru;Nishino, Ichizo

文献摘要

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目的：探讨包涵体肌炎（inclusion body myositis，IBM）与丙型肝炎病毒（hepatitis C virus，HCV）感染的相关性。方法：对2002 - 2012年114例IBM患者进行了肌肉活检病理学分析，并对44例年龄匹配的多发性肌炎患者进行了调查。我们还比较了临床病理特征，包括从发病到发展的IBM的代表性症状的持续时间和IBM与HCV感染和非感染之间的代表性病理变化的程度。结果：与多发性肌炎患者相比，IBM患者（28%）具有显着较高的抗HCV抗体（4.5%;比值比8.2，95%置信区间1.9-36）和60多岁的日本普通人群（3.4%）。此外，与IBM和没有HCV感染的患者之间，我们没有发现任何显着差异的临床病理特征，表明这2组基本上是相同的疾病，无论HCV infection.Conclusion：我们的研究结果提供了统计学证据IBM和HCV感染之间的关联，这表明可能的病理机制之间的联系2个条件。
Objective:To clarify whether there is any association between inclusion body myositis (IBM) and hepatitis C virus (HCV) infection.Methods:We assessed the prevalence of HCV infection in 114 patients with IBM whose muscle biopsies were analyzed pathologically for diagnostic purpose from 2002 to 2012 and in 44 age-matched patients with polymyositis diagnosed in the same period as a control by administering a questionnaire survey to the physicians in charge. We also compared clinicopathologic features including the duration from onset to development of representative symptoms of IBM and the extent of representative pathologic changes between patients with IBM with and without HCV infection.Results:A significantly higher number of patients with IBM (28%) had anti-HCV antibodies as compared with patients with polymyositis (4.5%; odds ratio 8.2, 95% confidence interval 1.9-36) and the general Japanese population in their 60s (3.4%). Furthermore, between patients with IBM with and without HCV infection, we did not find any significant difference in the clinicopathologic features, indicating that the 2 groups have essentially the same disease regardless of HCV infection.Conclusion:Our results provide the statistical evidence for an association between IBM and HCV infection, suggesting a possible pathomechanistic link between the 2 conditions.